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1. WO1996006094 - NOVEL SUBSTITUTED PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES

Publication Number WO/1996/006094
Publication Date 29.02.1996
International Application No. PCT/US1995/010640
International Filing Date 17.08.1995
Chapter 2 Demand Filed 26.02.1996
IPC
C07D 401/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 401/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 405/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
C07D 409/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14containing three or more hetero rings
C07D 417/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14containing three or more hetero rings
CPC
C07D 401/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 405/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
C07D 409/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14containing three or more hetero rings
C07D 417/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
14containing three or more hetero rings
Applicants
  • MERRELL PHARMACEUTICALS INC. [US/US]; 2110 East Galbraith Road P.O. Box 156300 Cincinnati, OH 45215-6300, US
Inventors
  • BURKHOLDER, Timothy, P.; US
  • BRATTON, Larry, D.; US
  • KUDLACZ, Elizabeth, M.; US
  • MAYNARD, George, D.; US
  • KANE, John, M.; US
  • SANTIAGO, Braulio; US
Agents
  • COLLIER, Kenneth, J.; Hoechst Marion Roussel, Inc. 2110 East Galbraith Road P.O. Box 156300 Cincinnati, OH 45215-6300, US
  • STEMERICK, David, M.; Hoechst Marion Roussel, Inc. 2110 East Galbraith Road P.O. Box 156300 Cincinnati, OH 45215-6300, US
Priority Data
08/295,96025.08.1994US
08/501,91413.07.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL SUBSTITUTED PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES
(FR) NOUVELLES PIPERIDINES SUBSTITUEES UTILES POUR LE TRAITEMENT D'AFFECTIONS ALLERGIQUES
Abstract
(EN)
The present invention relates to novel substituted piperidine derivatives of formula (1), stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonists. Such antagonists are useful in the treatment of allergic diseases including: seasonal rhinitis, allergic rhinitis, and sinusitis.
(FR)
La présente invention concerne de nouveaux dérivés de pipéridine substitués de la formule (1), ainsi que leurs stéréo-isomères et leurs sels acceptables sur le plan pharmaceutique, qui sont utiles comme antagonistes des récepteurs à l'histamine et comme antagonistes des récepteurs à la tachykinine. Ces antagonistes sont utiles pour le traitement d'affections allergiques telles que les rhinites saisonnières, les rhinites allergiques et les sinusites.
Also published as
FI970771
NO19970831
NZ292683
Latest bibliographic data on file with the International Bureau