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1. WO1996006085 - PROCESS FOR PREPARING CHIRAL TETRACYCLIC DOPAMINERGIC COMPOUNDS

Publication Number WO/1996/006085
Publication Date 29.02.1996
International Application No. PCT/US1995/009859
International Filing Date 03.08.1995
Chapter 2 Demand Filed 12.03.1996
IPC
C07D 221/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
221Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/-C07D219/187
02condensed with carbocyclic rings or ring systems
04Ortho- or peri-condensed ring systems
18Ring systems of four or more rings
C07D 491/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
491Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 495/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
C07D 221/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
221Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
02condensed with carbocyclic rings or ring systems
04Ortho- or peri-condensed ring systems
18Ring systems of four or more rings
C07D 491/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
491Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 495/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • ABBOTT LABORATORIES [US/US]; CHAD 0377/AP6D-2 100 Abbott Park Road Abbott Park, IL 60064-3500, US
Inventors
  • EHRLICH, Paul, P.; US
  • MICHAELIDES, Michael, R.; US
  • MCLAUGHLIN, Maureen, A.; US
  • HSAIO, Chi-Nung; US
Agents
  • BRAINARD, Thomas, D. ; Abbott Laboratories CHAD 0377/AP6D-2 100 Abbott Park Road Abbott Park, IL 60064-3500, US
Priority Data
08/292,67718.08.1994US
08/463,32605.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR PREPARING CHIRAL TETRACYCLIC DOPAMINERGIC COMPOUNDS
(FR) PROCEDE DE PREPARATION DE COMPOSES DOPAMINERGIQUES TETRACYCLIQUES CHIRAUX
Abstract
(EN)
A process for preparing a chiral tetracyclic compound of formula (1), wherein R is hydrogen or a C1-C6-alkyl group and Z is oxygen, sulfur or -CH=CH-, the compounds having uses as dopamine agonists. The process involves reacting a chiral starting material and subsequent chiral intermediates in a series of chirality-preserving synthetic reactions.
(FR)
Procédé de préparation d'un composé tétracyclique chiral de la formule (1), dans laquelle R représente hydrogène ou un groupe alkyle C1-C6 et Z représente oxygène, soufre ou -CH=CH-, ces composés agissant comme agonistes de la dopamine. Ce procédé consiste à faire réagir une matière de départ chirale et des intermédiaires chiraux ultérieurement formés en une série de réactions de synthèse maintenant la chiralité.
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