Processing

Please wait...

Settings

Settings

1. WO1996006082 - DIHYDROPYRIDINE DERIVATIVES AS BRADYKININ ANTAGONISTS

Publication Number WO/1996/006082
Publication Date 29.02.1996
International Application No. PCT/IB1995/000400
International Filing Date 26.05.1995
Chapter 2 Demand Filed 08.11.1995
IPC
C07D 211/90 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
80having two double bonds between ring members or between ring members and non-ring members
84with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
90Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
C07D 401/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 401/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 405/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 409/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 451/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
451Heterocyclic compounds containing 8-azabicyclo octane, 9-azabicyclo nonane, or 3-oxa-9-azatricyclo nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
02containing not further condensed 8-azabicyclo octane or 3-oxa-9-azatricyclo nonane ring systems, e.g. tropane; Cyclic acetals thereof
04with hetero atoms directly attached in position 3 of the 8-azabicyclo octane or in position 7 of the 3-oxa-9-azatricyclo nonane ring system
CPC
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
C07D 211/90
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
80having two double bonds between ring members or between ring members and non-ring members
84with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
90Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
C07D 401/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 405/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
Applicants
  • PFIZER INC. [US/US]; 235 East 42nd Street New York, NY 10017, US (AT, AU, BE, CA, CH, CN, DE, DK, ES, FI, FR, GB, GR, IE, IT, KR, LU, MC, MX, NL, NO, NZ, PT, SE)
  • PFIZER PHARMACEUTICALS INC. [JP/JP]; Shinjuku Mitsui Building 1-1, Nishi-shinjuku 2-chome Shinjuku-ku Tokyo 163-04, JP (JP)
  • ITO, Fumitaka [JP/JP]; JP (UsOnly)
  • KONDO, Hiroshi [JP/JP]; JP (UsOnly)
  • HAGEMAN, David, L. [US/US]; US (UsOnly)
  • LOWE, John, A., III [US/US]; US (UsOnly)
  • NAKANISHI, Susumu [US/US]; US (UsOnly)
  • VINICK, Fredric, J. [US/US]; US (UsOnly)
Inventors
  • ITO, Fumitaka; JP
  • KONDO, Hiroshi; JP
  • HAGEMAN, David, L.; US
  • LOWE, John, A., III; US
  • NAKANISHI, Susumu; US
  • VINICK, Fredric, J.; US
Agents
  • SPIEGEL, Allen, J.; Pfizer Inc. 235 East 42nd Street New York, NY 10017, US
Priority Data
PCT/JP94/0139824.08.1994JP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DIHYDROPYRIDINE DERIVATIVES AS BRADYKININ ANTAGONISTS
(FR) DERIVES DIHYDROPYRIDINES UTILISES EN TANT QU'ANTAGONISTES DES BRADYKININES
Abstract
(EN)
A compound of formula (I) and its pharmaceutically acceptable salts, wherein A1 and A2 are each halo; X is direct bond, CH2, CO, O, S, S(O) or S(O)2; R1 is selected from a variety of groups such as hydrogen; substituted or unsubstituted C1-4 alkyl; substituted or unsubstituted piperidinyl; substituted or unsubstituted C5-14 cycloalkyl, bicycloalkyl or tricycloalkyl; substituted or unsubstituted C7-14 azacyclo-, azabicyclo- or azatricyclo-alkyl; bicyclo C7-10 alkenyl; benzocyclo C5-7 alkyl; and heterocyclic; R2 is hydrogen, C1-4 alkyl, substituted or unsubstituted phenyl or heterocyclic; and R3 and R4 are each C1-5 alkyl. The novel dihydropyridine compounds of this invention have excellent bradykinin antagonistic activity and are thus useful for the treatment of inflammation, cardiovascular disease, pain, common cold, allergies, asthma, pancreatitis, burns, virus infection, head injury, multiple trauma or the like in mammalian, especially humans.
(FR)
Composé de la formule (I), ainsi que ses sels acceptables sur le plan pharmaceutique, dans laquelle A1 et A2 représentent chacun halo; X représente une liaison directe, CH2, CO, O, S, S(O) ou S(O)2; R1 est choisi parmi plusieurs groupes tels qu'hydrogène; alkyle C1-4 substitué ou non, pipéridinyle substitué ou non; cycloalkyle, bicycloalkyle ou tricycloalkyle C5-14 substitués ou non; azacyclo-, azabicyclo- ou azatricycloalkyle C7-14, substitués ou non; bicyclo-alcényle C7-10; benzocyclo-alkyle C5-7; et hétérocyclique; R2 représente hydrogène, alkyle C1-4, phényle substitué ou non, ou hétérocyclique; et R3 et R4 représentent chacun alkyle C1-5. Les nouveaux composés dihydropyridine de cette invention possèdent une excellente activité antagoniste des bradykinines et sont par conséquent utiles dans le traitement, chez les mammifères et notamment chez l'homme, de l'inflammation, des maladies cardio-vasculaires, de la douleur, du rhume banal, des allergies, de l'asthme, de la pancréatite, des brûlures, des infections à virus, des traumatismes crâniens, des traumatismes multiples ou analogues.
Also published as
FI970745
NO19970806
NZ285155
Latest bibliographic data on file with the International Bureau