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1. WO1996006069 - D-B-LYSYLMETHANEDIAMINE DERIVATIVES WITH BACTERIA, AIDS VIRUS AND TUMOR CELL GROWTH INHIBITING ACTIVITY AND PREPARATION THEREOF

Publication Number WO/1996/006069
Publication Date 29.02.1996
International Application No. PCT/JP1995/001680
International Filing Date 24.08.1995
Chapter 2 Demand Filed 01.09.1995
IPC
C07C 237/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
237Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
02having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
04the carbon skeleton being acyclic and saturated
10having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
CPC
C07C 237/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
237Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
02having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
04the carbon skeleton being acyclic and saturated
10having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
Applicants
  • ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI [JP/JP]; 14-23, Kami Ohsaki 3-chome Shinagawa-ku Tokyo 141, JP (AllExceptUS)
  • KONDO, Shinichi [JP/JP]; JP (UsOnly)
  • IKEDA, Yoko [JP/JP]; JP (UsOnly)
  • TAKEUCHI, Tomio [JP/JP]; JP (UsOnly)
  • SHINEI, Rie [JP/JP]; JP (UsOnly)
  • GOMI, Shuichi [JP/JP]; JP (UsOnly)
  • SHIBAHARA, Seiji [JP/JP]; JP (UsOnly)
  • HOSHINO, Hiroo [JP/JP]; JP (UsOnly)
Inventors
  • KONDO, Shinichi; JP
  • IKEDA, Yoko; JP
  • TAKEUCHI, Tomio; JP
  • SHINEI, Rie; JP
  • GOMI, Shuichi; JP
  • SHIBAHARA, Seiji; JP
  • HOSHINO, Hiroo; JP
Agents
  • YAGITA, Shigeru ; Bussan Building Bekkan 1-15, Nishi Shimbashi 1-chome Minato-ku Tokyo 105, JP
Priority Data
6/22083024.08.1994JP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) D-B-LYSYLMETHANEDIAMINE DERIVATIVES WITH BACTERIA, AIDS VIRUS AND TUMOR CELL GROWTH INHIBITING ACTIVITY AND PREPARATION THEREOF
(FR) DERIVES DE D-B-LYSYLMETHANEDIAMINE A ACTIVITE INHIBITRICE DES BACTERIES, DU VIRUS DU SIDA ET DE LA CROISSANCE DE CELLULES TUMORALES ET PREPARATION DESDITS DERIVES
Abstract
(EN)
Now are provided (R)-3,6-diamino-N-($g(v)-aminoalkyl)-hexanamides which are novel compounds having general formula (I), wherein n stands for 2-5, and which may be for example, (R)-3,6-diamino-N-(2-aminoethyl)hexanamide (n = 2) and (R)-3,6-diamino-N-(3-aminopropyl)hexanamide (n = 3). Their preparation process is also provided. These novel compounds and acid addition salts thereof have activities inhibitory against Gram-positive bacteria, Gram-negative bacteria and AIDS virus, as well as tumor cells and are chemically stable. These novel compounds and their salts are useful as chemotherapeutic agents for diseases caused by these bacteria or virus and also as antitumor agent.
(FR)
(R)-3,6-diamino-N-($g(v)-aminoalkyle)-hexanamides qui sont des nouveaux composés de formule générale (I) dans laquelle n vaut un nombre compris entre 2 et 5 inclus, et qui peuvent être par exemple (R)-3,6-diamino-N-(2-aminoéthyl)hexanamide (n = 2) et (R)-3,6-diamino-N-(2-aminopropyl)hexanamide (n = 3). Les procédés de préparation desdits composés sont également décrits. Lesdits nouveaux composés et leurs sels d'addition d'acide ont une activité inhibitrice contre les bactéries à Gram-positif, les bactéries à Gram-négatif et le virus du sida, ainsi que contre les cellules tumorales, et ils sont chimiquement stables. Ces nouveaux composés et leurs sels sont utiles en tant qu'agents de chimiothérapie pour des maladies causées par ces bactéries ou virus et également en tant qu'agents antitumoraux.
Also published as
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