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1. WO1996005867 - COMPOSITIONS

Publication Number WO/1996/005867
Publication Date 29.02.1996
International Application No. PCT/GB1995/001969
International Filing Date 18.08.1995
Chapter 2 Demand Filed 18.03.1996
IPC
A61K 49/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
A61K 49/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
18characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
CPC
A61K 49/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
08characterised by the carrier
A61K 49/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
18characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
A61K 49/1818
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
18characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
1818particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
A61K 49/1863
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
18characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
1818particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
1821coated or functionalised microparticles or nanoparticles
1824coated or functionalised nanoparticles
1827having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
1851having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
1863the organic macromolecular compound being a polysaccharide or derivative thereof, e.g. chitosan, chitin, cellulose, pectin, starch
Applicants
  • NYCOMED IMAGING A/S [NO/NO]; Nycoveien 2 N-0401 Oslo, NO (AllExceptUS)
  • COCKBAIN, Julian [GB/GB]; GB (GB)
  • GOLMAN, Klaes [DK/DK]; DK (UsOnly)
  • PETTERSSON, Göran [SE/SE]; SE (UsOnly)
  • BERG, Arne [NO/NO]; NO (UsOnly)
  • KLAVENESS, Jo [NO/NO]; NO (UsOnly)
  • RONGVED, Pål [NO/NO]; NO (UsOnly)
  • LEANDER, Peter [SE/SE]; SE (UsOnly)
  • LEUNBACH, Ib [DK/DK]; DK (UsOnly)
  • GUNTHER, Wolfgang [US/US]; US (UsOnly)
Inventors
  • GOLMAN, Klaes; DK
  • PETTERSSON, Göran; SE
  • BERG, Arne; NO
  • KLAVENESS, Jo; NO
  • RONGVED, Pål; NO
  • LEANDER, Peter; SE
  • LEUNBACH, Ib; DK
  • GUNTHER, Wolfgang; US
Agents
  • COCKBAIN, Julian ; Frank B. Dehn & Co. 179 Queen Victoria Street GB-London EC4V 4EL, GB
Priority Data
9416767.318.08.1994GB
9416768.118.08.1994GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS
(FR) COMPOSITIONS
Abstract
(EN)
There is provided a contrast medium composition comprising a physiologically tolerable manganese compound, an uptake promoter and a physiologically tolerable carrier or excipient, having a manganese concentration of at least 0.3mM or being in a dosage unit form containing at least 300 $g(m)mol manganese, wherein the uptake promoter comprises a physiologically tolerable reducing compound containing an $g(a)-hydroxy ketone group, a physiologically tolerable acid containing $g(a)- and/or $g(b)-hydroxy or amino groups, or a salt thereof, and/or vitamin D. Such compositions are particularly suitable for imaging of the liver.
(FR)
On décrit une composition de milieu de contraste qui contient un composé à base de manganèse tolérable du point de vue physiologique, un promoteur d'absorption et un vecteur ou excipient tolérable du point de vue physiologique. Sa concentration en manganèse est d'au moins 0,3 mM mais elle peut aussi se présenter sous une forme galénique contenant au moins 300 $g(m)mol de manganèse. Le promoteur d'absorption comprend un composé réducteur, tolérable du point de vue physiologique, qui contient un groupe $g(a)-hydroxy cétone, un acide tolérable du point de vue physiologique et contenant des groupes $g(a) et/ou $g(b)-hydroxy ou amino ou un de leurs sels, et/ou de la vitamine D. Ces compositions conviennent particulièrement pour l'imagerie du foie.
Also published as
FI970667
NO19970747
NZ291479
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