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1. WO1996005856 - HUMAN CHEMOKINE POLYPEPTIDES

Publication Number WO/1996/005856
Publication Date 29.02.1996
International Application No. PCT/US1994/009484
International Filing Date 23.08.1994
Chapter 2 Demand Filed 28.02.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/52 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
C07K 14/523
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
521Chemokines
523Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
Applicants
  • HUMAN GENOME SCIENCES, INC. [US/US]; Suite 300 9620 Medical Center Drive Rockville, MD 20850-3338, US (AllExceptUS)
  • LI, Haodong [CN/US]; US (UsOnly)
  • ADAMS, Mark, D. [US/US]; US (UsOnly)
Inventors
  • LI, Haodong; US
  • ADAMS, Mark, D.; US
Agents
  • OLSTEIN, Elliot, M. ; Carella, Byrne, Bain, Gilfillan, Cecchi, Stewart & Olstein 6 Becker Farm Road Roseland, NJ 07068, US
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HUMAN CHEMOKINE POLYPEPTIDES
(FR) POLYPEPTIDES DE TYPE CHEMOKINE HUMAINE
Abstract
(EN)
Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.
(FR)
Polypeptides de type chémokine humaine, ADN (ARN) codant lesdits polypeptides et procédé de production desdits polypeptides par des techniques de recombinaison. Des procédés d'utilisation desdits polypeptides dans le traitement de la leucémie, des tumeurs, des infections chroniques, des maladies auto-immunes, des fibroses, de la cicatrisation et du psoriasis sont également décrits, ainsi que des antagonistes desdits polypeptides et leur utilisation en tant qu'agents thérapeutiques pour traiter la polyarthrite chronique évolutive, les inflammations auto-immunes et chroniques et les maladies infectieuses, les réactions allergiques, la fièvre indépendante des prostaglandines et l'insuffisance médullaire.
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