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1. WO1996005854 - COMBINATION PREPARATION, CONTAINING CYCLOSPORIN A OR FK506 OR RAPAMYCIN AND A XANTHINE DERIVATIVE

Publication Number WO/1996/005854
Publication Date 29.02.1996
International Application No. PCT/EP1995/003126
International Filing Date 07.08.1995
Chapter 2 Demand Filed 15.03.1996
IPC
A61K 31/453 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
445Non-condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
453containing a six-membered ring with oxygen as a ring hetero atom
A61K 38/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12Cyclic peptides
A61K 38/13 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12Cyclic peptides
13Cyclosporins
CPC
A61K 31/453
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
445Non condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
453containing a six-membered ring with oxygen as a ring hetero atom
A61K 38/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12Cyclic peptides ; , e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
A61K 38/13
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12Cyclic peptides ; , e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
13Cyclosporins
Applicants
  • HOECHST AKTIENGESELLSCHAFT [DE/DE]; Brüningstrasse 50 D-65929 Frankfurt am Main, DE (AT, BE, CA, CH, CN, DE, DK, ES, FR, GB, GR, IE, IT, JP, LU, MC, MX, NL, PT, SE)
  • KATHOLIEKE UNIVERSITEIT LEUVEN [BE/BE]; Oude Markt 13 B-3000 Leuven, BE (AllExceptUS)
  • SCHÖNHARTING, Martin [DE/DE]; DE (UsOnly)
  • GEBERT, Ulrich [DE/DE]; DE (UsOnly)
  • WAER, Mark [BE/BE]; BE (UsOnly)
Inventors
  • SCHÖNHARTING, Martin; DE
  • GEBERT, Ulrich; DE
  • WAER, Mark; BE
Common Representative
  • HOECHST AKTIENGESELLSCHAFT; Patent- und Lizenzabteilung, Gebäude K801 D-65926 Frankfurt am Main, DE
Priority Data
P 44 30 127.825.08.1994DE
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMBINATION PREPARATION, CONTAINING CYCLOSPORIN A OR FK506 OR RAPAMYCIN AND A XANTHINE DERIVATIVE
(FR) PREPARATION D'ASSOCIATIONS CONTENANT UNE CYCLOSPORINE A OU FK506 OU LA RAPAMYCINE AINSI QU'UN DERIVE XANTHINE
Abstract
(EN)
Combination preparations which contain cyclosporin A and a xanthine derivative or FK506 and a xanthine derivative or rapamycin and a xanthine derivative are suitable for use in organ transplantation, cancer, viral diseases or in autoimmune disorders such as systemic lupus erythematosus, rheumatoid arthritis, psoriasis, pemphigus, atopic dermatitis, myositis, multiple sclerosis, nephrotic syndrome (in particular glomerulonephritis), ulcerative colitis or juvenile diabetes.
(FR)
Préparation d'associations contenant une cyclosporine A et un dérivé xanthine, ou FK506 et un dérivé xanthine, ou la rapamycine et un dérivé xanthine, conçues pour être utilisées dans la transplantation d'organe, ou le traitement du cancer, des maladies virales ou des états auto-immuns tels que le lupus érythémateux aigu disséminé, la polyarthrite rhumatoïde, le psoriasis, le pemphigus, la dermatite atopique, la myosite, la sclérose en plaques, le syndrome néphrotique (notamment la glomérulonéphrite), la rectocolite hémorragique ou le diabète juvénile.
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