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1. WO1996005843 - PHARMACEUTICAL COMPOSITIONS COMPRISING CO-DRIED SUCRALFATE GEL AND POLYALCOHOL

Publication Number WO/1996/005843
Publication Date 29.02.1996
International Application No. PCT/EP1995/003189
International Filing Date 11.08.1995
Chapter 2 Demand Filed 12.03.1996
IPC
A61K 9/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
16Agglomerates; Granulates; Microbeadlets
A61K 47/26 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
CPC
A61K 31/7024
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7024Esters of saccharides
A61K 47/26
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 9/1623
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605Excipients; Inactive ingredients
1617Organic compounds, e.g. phospholipids, fats
1623Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Applicants
  • ENOSYS S.A. [CH/CH]; Via Dufour, 2 CH-6900 Lugano, CH (AllExceptUS)
  • COLOMBO, Paolo [IT/IT]; IT (UsOnly)
  • ZAGNOLI, Giorgio [IT/IT]; IT (UsOnly)
  • CONTOS, Simos [IT/IT]; IT (UsOnly)
Inventors
  • COLOMBO, Paolo; IT
  • ZAGNOLI, Giorgio; IT
  • CONTOS, Simos; IT
Agents
  • MINOJA, Fabrizio; Studio Consulenza Brevettuale Via Rossini, 8 I-20122 Milano, IT
Priority Data
MI94A00177525.08.1994IT
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PHARMACEUTICAL COMPOSITIONS COMPRISING CO-DRIED SUCRALFATE GEL AND POLYALCOHOL
(FR) COMPOSITIONS PHARMACEUTIQUES COMPRENANT UN GEL DE SUCRALFATE ET UN POLYALCOOL SECHES EN MEME TEMPS
Abstract
(EN)
A process for the preparation of sucralfate gel, in the dry state, that does not lose its colloidal properties is disclosed. Moreover, taking into consideration the particular tropism of sucralfate gel towards the gastric mucosa and its properties of bioadhesion, the claim is extended to the use of dry sucralfate gel as a carrier for medicaments intended for the treatment of $i(Helicobacter pylori) infections as antibiotics, antibacterials, antiinflammatories, or in order to maintain for as long as possible antisecretory drugs, such as cimetidine, ranitidine, prostaglandins and omeprazol, in the gastric environment.
(FR)
Procédé de préparation d'un gel de sucralfate, à l'état sec, ne perdant pas ses propriétés colloïdales. En outre, compte tenu du tropisme particulier du gel de sucralfate à l'égard de la muqueuse gastrique et de ses caractéristiques de bioadhésion, on revendique l'utilisation de ce gel de sucralfate sec en tant qu'excipient pour médicaments destinés au traitement d'infections à $i(Helicobacter pylori), tels que des antibiotiques, des antibactériens, des anti-inflammatoires, ou en tant qu'excipient servant à maintenir aussi longtemps que possible des médicaments antisécrétoires, tels que la cimétidine, la ranitidine, les prostaglandines et l'oméprazole, dans la sphère gastrique.
Also published as
Latest bibliographic data on file with the International Bureau