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1. WO1996005838 - COMBINED PREPARATION FOR THE THERAPY OF IMMUNE DISEASES

Publication Number WO/1996/005838
Publication Date 29.02.1996
International Application No. PCT/EP1995/003125
International Filing Date 07.08.1995
Chapter 2 Demand Filed 15.03.1996
IPC
A61K 38/13 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12Cyclic peptides
13Cyclosporins
A61K 45/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
CPC
A61K 31/522
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
52Purines, e.g. adenine
522having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
A61K 31/554
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
554having at least one nitrogen and one sulfur as ring hetero atoms, e.g. chlothiapine, diltiazem
A61K 38/13
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12Cyclic peptides ; , e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
13Cyclosporins
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
Applicants
  • HOECHST AKTIENGESELLSCHAFT [DE]/[DE] (AllExceptUS)
  • SCHÖNHARTING, Martin [DE]/[DE] (UsOnly)
  • MÜLLNER, Stefan [DE]/[DE] (UsOnly)
  • ZABEL, Peter [DE]/[DE] (UsOnly)
Inventors
  • SCHÖNHARTING, Martin
  • MÜLLNER, Stefan
  • ZABEL, Peter
Priority Data
P 44 30 128.625.08.1994DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) KOMBINATIONSPRÄPARAT ZUR ANWENDUNG BEI IMMUNOLOGISCHEN ERKRANKUNGEN
(EN) COMBINED PREPARATION FOR THE THERAPY OF IMMUNE DISEASES
(FR) PREPARATION COMBINEE POUR LE TRAITEMENT DE MALADIES IMMUNITAIRES
Abstract
(DE)
Ein Kombinationspräparat, enthaltend eine Verbindung, die eine Phosphodiesterase-Hemmwirkung aufweist, und eine Verbindung, die den biologisch effektiven intrazellulären Ca2+-Gehalt vermindert, eignet sich zur Behandlung von immunologischen Erkrankungen. Beispiele hierfür sind die folgenden Kombinationen: Pentoxifyllin und Nifedipin, Pentoxifyllin und Diltiazem, Pentoxifyllin und Verapamil, Pentoxifyllin und Cyclosporin A, sowie Vinpocetin und Diltiazem.
(EN)
A combined preparation contains a compound with a phosphodiesterase inhibiting effect and a compound that reduces the biologically effective intracellular Ca2+ content. This preparation is suitable for treating immune diseases. Such a preparation can, for example, contain the following combinations: pentoxifylline and nifedipine, pentoxifylline and diltiazem, pentoxifylline and verapamil, pentoxifylline and cyclosporine A, as well as vincopectine and diltiazem.
(FR)
Une préparation combinée contient un composé avec un effet inhibiteur de la phosphodiestérase et un composé qui réduit la teneur en Ca2+ intracellulaire biologiquement efficace. Cette préparation est utile pour traiter des maladies immunitaires. La préparation présentée peut, par exemple, contenir les combinaisons suivantes: pentoxifylline et nifédipine, pentoxifylline et diltiazem, pentoxifylline et véramapil, pentoxifylline et cyclosporine A, ainsi que vincopétine et diltiazem.
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