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1. WO1996005837 - USE OF N-SUBSTITUTED PHENOTHIAZINES

Publication Number WO/1996/005837
Publication Date 29.02.1996
International Application No. PCT/EP1995/003212
International Filing Date 14.08.1995
Chapter 2 Demand Filed 08.03.1996
IPC
A61K 31/54 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
54having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
C07D 279/26 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
279Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
101,4-Thiazines; Hydrogenated 1,4-thiazines
14condensed with carbocyclic rings or ring systems
18-condensed with two six-membered rings
22with carbon atoms directly attached to the ring nitrogen atom
24with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
26without other substituents attached to the ring system
C07D 279/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
279Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
101,4-Thiazines; Hydrogenated 1,4-thiazines
14condensed with carbocyclic rings or ring systems
18-condensed with two six-membered rings
22with carbon atoms directly attached to the ring nitrogen atom
24with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
28with other substituents attached to the ring system
C07D 279/30 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
279Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
101,4-Thiazines; Hydrogenated 1,4-thiazines
14condensed with carbocyclic rings or ring systems
18-condensed with two six-membered rings
22with carbon atoms directly attached to the ring nitrogen atom
30with acyl radicals attached to the ring nitrogen atom
C07D 417/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
A61K 31/54
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
54having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
A61P 1/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
08for nausea, cinetosis or vertigo; Antiemetics
A61P 13/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
02of urine or of the urinary tract, e.g. urine acidifiers
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
02for peripheral neuropathies
Applicants
  • BAYER AKTIENGESELLSCHAFT [DE]/[DE] (AllExceptUS)
  • URBAHNS, Klaus [DE]/[DE] (UsOnly)
  • HEINE, Hans-Georg [DE]/[DE] (UsOnly)
  • JUNGE, Bodo [DE]/[DE] (UsOnly)
  • SCHOHE-LOOP, Rudolf [DE]/[DE] (UsOnly)
  • SOMMERMEYER, Henning [DE]/[DE] (UsOnly)
  • GLASER, Thomas [DE]/[DE] (UsOnly)
  • WITTKA, Reilinde [DE]/[DE] (UsOnly)
  • DE VRY, Jean-Marie-Viktor [BE]/[DE] (UsOnly)
Inventors
  • URBAHNS, Klaus
  • HEINE, Hans-Georg
  • JUNGE, Bodo
  • SCHOHE-LOOP, Rudolf
  • SOMMERMEYER, Henning
  • GLASER, Thomas
  • WITTKA, Reilinde
  • DE VRY, Jean-Marie-Viktor
Common Representative
  • BAYER AKTIENGESELLSCHAFT
Priority Data
P 44 30 091.325.08.1994DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) VERWENDUNG VON N-SUBSTITUIERTEN PHENOTHIAZINEN
(EN) USE OF N-SUBSTITUTED PHENOTHIAZINES
(FR) UTILISATION DE PHENOTHIAZINES SUBSTITUEES PAR N
Abstract
(DE)
Die Erfindung betrifft die Verwendung von N-substituierten Phenothiazinen zur Herstellung von Arzneimitteln zur Behandlung von cerebralen Erkrankungen. Ebenso betrifft die Erfindung neue Wirkstoffe, die durch Umsetzung von Phenothiazin mit den entsprechenden Säuren, Estern oder Amiden oder durch Umsetzung der Phenothiazincarbonsäurehalogenide mit Aminen hergestellt werden. Die Wirkstoffe eignen sich insbesondere zur Behandlung von Demenzen sowie altersbedingten Lern- und Gedächtnisstörungen und Depressionen.
(EN)
The invention concerns the use of N-substituted phenothiazines for producing drugs for treating cerebral disorders. The invention also concerns novel active substances prepared by reacting phenothiazine with the appropriate acids, esters or amides or by reacting phenothiazine carboxylic acid halides with amines. The active substances are in particular suitable for treating dementia, depression and learning and memory disorders caused by old age.
(FR)
L'invention concerne l'utilisation de phénothiazines substituées par N, pour la production de médicaments destinés au traitement des maladies cérébrales. L'invention concerne également de nouveaux principes actifs fabriqués par réaction de phénothiazine avec des acides, esters ou amides appropriés ou par réaction d'halogénure d'acide carboxylique de phénothiazine avec des amines. Ces principes actifs sont utilisés en particulier dans le traitement des démences ainsi que des troubles de la mémoire et des facultés d'apprentissage, liés à la vieillesse, et des dépressions.
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