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1. WO1996005828 - PYRROLIDINYL DI-CARBOXYLIC ACID DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS

Publication Number WO/1996/005828
Publication Date 29.02.1996
International Application No. PCT/US1995/010320
International Filing Date 14.08.1995
Chapter 2 Demand Filed 29.02.1996
IPC
C07D 207/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04having no double bonds between ring members or between ring members and non-ring members
10with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
CPC
A61P 1/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
08for nausea, cinetosis or vertigo; Antiemetics
C07D 207/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04having no double bonds between ring members or between ring members and non-ring members
10with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Applicants
  • ELI LILLY AND COMPANY [US/US]; Lilly Corporate Center Indianapolis, IN 46285, US (AllExceptUS)
  • MONN, James, Allen [US/US]; US (UsOnly)
  • TIZZANO, Joseph, Patrick [US/US]; US (UsOnly)
  • VALLI, Matthew, J. [US/US]; US (UsOnly)
Inventors
  • MONN, James, Allen; US
  • TIZZANO, Joseph, Patrick; US
  • VALLI, Matthew, J.; US
Agents
  • LAMMERT, Steven, R.; Barnes & Thornburg 1313 Merchants Bank Building 11 South Meridian Street Indianapolis, IN 46204, US
Priority Data
08/295,33724.08.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PYRROLIDINYL DI-CARBOXYLIC ACID DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS
(FR) DERIVES DE L'ACIDE PYRROLIDINYLDICARBOXYLIQUE ANTAGONISTES DES RECEPTEURS DU GLUTAMATE METABOTROPE
Abstract
(EN)
The present invention provides pyrrolidinyl di-carboxylic acid derivatives that affect certain excitatory amino acid receptors, and are useful in the treatment of neurological disorders and psychiatric disorders. This invention further provides novel pyrrolidinyl di-carboxylic acid derivatives and pharmaceutical formulations employing these novel compounds.
(FR)
L'invention porte sur des dérivés de l'acide pyrrolidinyldicarboxylique affectant certains récepteurs d'acides aminés excitateurs et s'avérant utiles dans le traitement de troubles neurologiques et psychiatriques. L'invention porte également sur de nouveaux dérivés de l'acide pyrrolidinyldicarboxylique et sur des préparations pharmaceutiques les contenant.
Also published as
Latest bibliographic data on file with the International Bureau