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1. WO1996005810 - DRUG DELIVERY COMPOSITION CONTAINING CHITOSAN OR DERIVATIVE THEREOF HAVING A DEFINED Z. POTENTIAL

Publication Number WO/1996/005810
Publication Date 29.02.1996
International Application No. PCT/GB1995/001980
International Filing Date 21.08.1995
Chapter 2 Demand Filed 16.02.1996
IPC
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 9/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
16Agglomerates; Granulates; Microbeadlets
CPC
A61K 9/0043
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0043Nose
A61K 9/1652
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605Excipients; Inactive ingredients
1629Organic macromolecular compounds
1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Y10T 428/2982
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
428Stock material or miscellaneous articles
29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
2982Particulate matter [e.g., sphere, flake, etc.]
Applicants
  • DANBIOSYST UK LIMITED [GB/GB]; Albert Einstein Centre Highfields Science Park Nottingham NG7 2TN, GB (AllExceptUS)
  • WATTS, Peter, James [GB/GB]; GB (UsOnly)
  • ILLUM, Lisbeth [DK/GB]; GB (UsOnly)
Inventors
  • WATTS, Peter, James; GB
  • ILLUM, Lisbeth; GB
Agents
  • BASSETT, Richard; Eric Potter Clarkson St. Mary's Court St. Mary's Gate Nottingham NG1 1LE, GB
Priority Data
9416884.620.08.1994GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DRUG DELIVERY COMPOSITION CONTAINING CHITOSAN OR DERIVATIVE THEREOF HAVING A DEFINED Z. POTENTIAL
(FR) COMPOSITION D'APPORT DE MEDICAMENTS CONTENANT DU CHITOSANE, OU UN DE SES DERIVES, A POTENTIEL ZETA DEFINI
Abstract
(EN)
A drug delivery composition for administration to mucosa is provided. The composition comprises a pharmacologically active compound and particles, preferably powder or microspheres, of chitosan or a chitosan derivative or salt wherein the particles are either solidified or partially cross-linked such that they have a zeta-potential of +0.5 to +50 mV. Solidified particles are made by treating particles made from a water soluble chitosan salt with an alkaline agent such as sodium hydroxide in non-acid containing water to render them insoluble.
(FR)
On décrit une composition d'apport de médicaments destinée à être administrée aux muqueuses. Elle comprend un composé pharmacologiquement actif et des particules, de la poudre ou des microsphères de préférence, de chitosane ou d'un de sels ou dérivés, particules qui sont solidifiées ou partiellement réticulées de façon à présenter un potentiel zêta allant de +0,5 à +50 mV. On obtient des particules solidifiées en traitant des particules d'un sel de chitosane hydrosoluble avec un agent alcalin tel que l'hydroxyde de sodium dans une eau ne contenant aucun acide, ce qui les rend insolubles.
Also published as
FI970694
GB9702503.5
NO19970507
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