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1. WO1996005298 - ANTITUMOR ANTISENSE OLIGONUCLEOTIDES

Publication Number WO/1996/005298
Publication Date 22.02.1996
International Application No. PCT/EP1995/002985
International Filing Date 27.07.1995
Chapter 2 Demand Filed 09.02.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07H 21/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
C12N 15/11 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 13/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
02of urine or of the urinary tract, e.g. urine acidifiers
A61P 13/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
08of the prostate
A61P 13/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
10of the bladder
Applicants
  • CIBA-GEIGY AG [CH/CH]; Klybeckstrasse 141 CH-4002 Basle, CH (AllExceptUS)
  • METT, Helmut [DE/DE]; DE (UsOnly)
  • HÄNER, Robert [DE/DE]; DE (UsOnly)
  • DEAN, Nicholas, Mark [GB/US]; US (UsOnly)
Inventors
  • METT, Helmut; DE
  • HÄNER, Robert; DE
  • DEAN, Nicholas, Mark; US
Priority Data
08/287,75309.08.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTITUMOR ANTISENSE OLIGONUCLEOTIDES
(FR) OLIGONUCLEOTIDES ANTISENS ANTITUMORAUX
Abstract
(EN)
The invention relates to deoxyribo- and ribo-oligonucleotides and derivatives thereof, as well as pharmaceutical preparations, therapies, diagnostics and commercial research reagents in relation to disease states which respond to modulation of the synthesis of the enzyme S-adenosylmethionine decarboxylase (SAMDC). In particular, the invention relates to antisense oligonucleotides and oligonucleotide derivatives specifically hybridizable with nucleic acids relating to (preferably human) SAMDC, especially SAMDC cDNA. These oligonucleotides and their derivatives have been found to modulate the synthesis of SAMDC in cells and to be effective against e.g. tumor diseases.
(FR)
L'invention concerne des désoxyribo- et ribo-oligonucléotides et leurs dérivés, ainsi que des préparations pharmaceutiques, des traitements, des diagnostics et des réactifs d'étude commerciale en liaison avec des états pathologiques qui réagissent à la modulation de la synthèse de la S-adénosylméthionine-décarboxylase (SAMDC). L'invention concerne notamment des oligonucléotides et des dérivés d'oligonucléotides antisens s'hybridant spécifiquement avec des acides nucléiques en rapport avec la SAMDC (de préférence humaine), en particulier l'ADNc de SAMDC. Ces oligonucléotides et leurs dérivés se sont révélés moduler la synthèse de la SAMDC dans les cellules et être efficaces contre par exemple les affections tumorales.
Also published as
Latest bibliographic data on file with the International Bureau