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1. WO1996005294 - METHOD FOR PREPARING AN INFLUENZA VIRUS, ANTIGENS OBTAINED AND APPLICATIONS THEREOF

Publication Number WO/1996/005294
Publication Date 22.02.1996
International Application No. PCT/FR1995/000727
International Filing Date 06.06.1995
Chapter 2 Demand Filed 01.02.1996
IPC
A61K 39/145 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
145Orthomyxoviridae, e.g. influenza virus
C12N 7/06 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
04Inactivation or attenuation; Producing viral sub-units
06by chemical treatment
CPC
A61K 2039/5252
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5252inactivated (killed)
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61K 39/145
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
145Orthomyxoviridae, e.g. influenza virus
C12N 2760/16134
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2760ssRNA Viruses negative-sense
00011ssRNA Viruses negative-sense
16011Orthomyxoviridae
16111Influenzavirus A, i.e. influenza A virus
16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
C12N 2760/16163
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2760ssRNA Viruses negative-sense
00011ssRNA Viruses negative-sense
16011Orthomyxoviridae
16111Influenzavirus A, i.e. influenza A virus
16161Methods of inactivation or attenuation
16163by chemical treatment
C12N 7/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
Applicants
  • PASTEUR MERIEUX SERUMS ET VACCINS [FR/FR]; 58, avenue Leclerc F-69007 Lyon, FR (AllExceptUS)
  • VIOLAY, Jean-Michel [FR/FR]; FR (UsOnly)
  • COURT, Guy [FR/FR]; FR (UsOnly)
  • GERDIL, Catherine [FR/FR]; FR (UsOnly)
  • CHALUMEAU, Hervé [FR/FR]; FR (UsOnly)
  • Mc VERRY, Patrick [US/US]; US (UsOnly)
Inventors
  • VIOLAY, Jean-Michel; FR
  • COURT, Guy; FR
  • GERDIL, Catherine; FR
  • CHALUMEAU, Hervé; FR
  • Mc VERRY, Patrick; US
Agents
  • BERNASCONI, Jean ; Cabinet Lavoix 2, place d'Estienne-d'Orves F-75441 Paris Cédex 09, FR
Priority Data
94/1003916.08.1994FR
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) METHOD FOR PREPARING AN INFLUENZA VIRUS, ANTIGENS OBTAINED AND APPLICATIONS THEREOF
(FR) PROCEDE DE PREPARATION DU VIRUS GRIPPAL, ANTIGENS OBTENUS ET LEURS APPLICATIONS
Abstract
(EN)
Method for preparing purified influenzal antigens from a liquid containing the influenzal virus, comprising the steps of concentration, purification, fragmentation and optionally inactivation, characterized in that: A. either the purification step comprises a plurality of ultracentifugation steps separated by a filtration step, B. or the fragmentation step is carried out on the living virus in the presence of a non ionic amphiphilic detergent followed by the removal of undesirable substances by filtration retaining all of the viral constituents, or the method is carried out according to these two steps in any order.
(FR)
Procédé de préparation d'antigèns grippaux purifiés, à partir d'un liquide contenant le virus grippal, comprenant les étapes de concentration, de purification, de fragmentation et éventuellement d'inactivation caractérisé en ce que: A. ou bien l'étape de purification comporte plusieurs étapes d'ultracentrifugation séparées par une étape de filtration, B. ou bien l'étape de fragmentation est effectuée sur le virus vivant en présence d'un détergent non-ionique amphiphile suivie d'une élimination des substances indésirables par filtration retenant l'ensemble des constituants viraux, ou bien on opère selon ces deux étapes dans un ordre quelconque.
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