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1. (WO1996005289) ENHANCED ACTIVATION OF NATURAL KILLER CELLS USING AN NK CELL ACTIVATOR AND A HYDROGEN PEROXIDE SCAVENGER OR INHIBITOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1996/005289    International Application No.:    PCT/US1995/009514
Publication Date: 22.02.1996 International Filing Date: 28.07.1995
Chapter 2 Demand Filed:    31.01.1996    
IPC:
A61K 31/35 (2006.01), A61K 31/4045 (2006.01), A61K 31/415 (2006.01), A61K 31/417 (2006.01), A61K 35/14 (2006.01), A61K 38/00 (2006.01), A61K 38/19 (2006.01), A61K 38/20 (2006.01), A61K 38/21 (2006.01), A61K 38/44 (2006.01), A61K 45/06 (2006.01), A61P 43/00 (2006.01), C12N 5/0783 (2010.01)
Applicants: SYNTELLO, INC. [US/US]; Suite 310, 4350 Executive Drive, San Diego, CA 92121 (US)
Inventors: HELLSTRAND, Jan, Urban, Kristoffer; (SE).
HERMODSSON, Svante, Hermod; (SE)
Agent: ALTMAN, Daniel, E.; Knobbe, Martens, Olson and Bear, 16th floor, 620 Newport Center Drive, Newport Beach, CA 92660 (US)
Priority Data:
08/287,200 08.08.1994 US
Title (EN) ENHANCED ACTIVATION OF NATURAL KILLER CELLS USING AN NK CELL ACTIVATOR AND A HYDROGEN PEROXIDE SCAVENGER OR INHIBITOR
(FR) ACTIVATION AMPLIFIEE DE CELLULES TUEUSES NATURELLES AU MOYEN D'UN ACTIVATEUR DE CES CELLULES ET D'UN COMPOSE D'INHIBITION OU D'EPURATION DE PEROXYDE D'HYDROGENE
Abstract: front page image
(EN)An improved method for the prevention of the inactivation of natural killer (NK) cells and the enhanced activation of NK cells in the presence of monocytes using a combination of a natural killer cell activator and a compound effective to inhibit the production or release of intracellular hydrogen peroxide, or a hydrogen peroxide scavenger, is disclosed. The method is useful, for example, in the treatment of solid tumors, metastases and viral infection.
(FR)Procédé amélioré servant à empêcher l'inactivation de cellules tueuses naturelles (NK) et activation amplifiée desdites cellules en présence de monocytes au moyen d'une combinaison d'un activateur de cellules tueuses naturelles et d'un composé servant à inhiber la production ou la libération de peroxyde d'hydrogène intracellulaire ou à épurer le peroxyde d'hydrogène. Ce procédé est efficace, par exemple, dans le traitement de tumeurs solides, de métastases et d'infections virales.
Designated States: AU, CA, JP.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)