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1. WO1996005233 - LOW-MOLECULAR-WEIGHT ACETYLATED HYALURONIC ACID, EMOLLIENT, AND PROCESSES FOR PRODUCING AND PURIFYING THE ACID

Publication Number WO/1996/005233
Publication Date 22.02.1996
International Application No. PCT/JP1995/001613
International Filing Date 11.08.1995
IPC
A61K 8/73 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
72containing organic macromolecular compounds
73Polysaccharides
C08B 37/08 2006.01
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
BPOLYSACCHARIDES; DERIVATIVES THEREOF
37Preparation of polysaccharides not provided for in groups C08B1/-C08B35/110; Derivatives thereof
08Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
CPC
A61K 8/735
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
72containing organic macromolecular compounds
73Polysaccharides
735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
A61Q 19/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
A61Q 19/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
10Washing or bathing preparations
A61Q 5/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
5Preparations for care of the hair
C08B 37/0072
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
BPOLYSACCHARIDES; DERIVATIVES THEREOF
37Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
0072Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
Applicants
  • SHISEIDO CO., LTD. [JP/JP]; 5-5, Ginza 7-chome Chuo-ku Tokyo 104-10, JP (AllExceptUS)
  • OKA, Takashi [JP/JP]; JP (UsOnly)
  • YANAKI, Toshio [JP/JP]; JP (UsOnly)
  • YAMAGUCHI, Michihiro [JP/JP]; JP (UsOnly)
Inventors
  • OKA, Takashi; JP
  • YANAKI, Toshio; JP
  • YAMAGUCHI, Michihiro; JP
Agents
  • IWAHASHI, Yuji; 1-11-8, Higashikanagawa Kanagawa-ku Yokohama-shi Kanagawa 221, JP
Priority Data
6/21061111.08.1994JP
7/18615629.06.1995JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) LOW-MOLECULAR-WEIGHT ACETYLATED HYALURONIC ACID, EMOLLIENT, AND PROCESSES FOR PRODUCING AND PURIFYING THE ACID
(FR) ACIDE HYALURONIQUE ACETYLE A FAIBLE POIDS MOLECULAIRE, EMOLLIENT, ET PROCEDES D'OBTENTION ET DE PURIFICATION DE CET ACIDE
Abstract
(EN)
A low-molecular-weight acetylated hyaluronic acid having the following characteristics and an emollient containing the same as the active ingredient: limiting viscosity: 50 - 200 cm3/g, number of acetyl groups: 2.6 - 3.6 (except N-acetyl groups). The emollient can exhibit excellent emollient and humectant effects while appropriately controlling the stringiness of the hyaluronic acid. The process for producing the acid comprises suspending powdery hyaluronic acid in a solution of acetic anhydride and adding concentrated sulfuric acid to the solution to effect acetylation. The process for purifying the acid comprises adding crude acetylated hyaluronic acid to an aqueous solution of acetone, adding sodium lactate to the solution to effect dissolution of the acid, and precipitating high-purity acetylated hyaluronic acid by adding a high-concentration acetone solution.
(FR)
Acide hyaluronique acétylé à faible pouvoir moléculaire présentant les caractéristiques suivantes et émollient renfermant cet acide comme un principe actif: viscosité limite: 50-200 cm3 par gramme; nombre de groupes acétyles: 2,6 - 3,6 (groupes acétyles N exceptés). L'émollient peut présenter d'excellentes propriétés émollientes et humectantes tout en limitant de manière appropriée l'astringence de l'acide hyaluronique. Le procédé d'élaboration de l'acide consiste à réaliser une suspension d'acide hyaluronique en poudre dans une solution d'anhydride acétique et à ajouter de l'acide sulfurique concentré à la solution pour l'acétylation. L'épuration de l'acide consiste à ajouter de l'acide hyaluronique acétylé brut à une solution aqueuse d'acétone, à ajouter du lactate de sodium à la solution pour obtenir la dissolution de l'acide et à précipiter l'acide hyaluronique acétylé à haut degré de pureté en ajoutant une solution d'acétone à concentration élevée.
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