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1. WO1996005232 - APOPTOSIS RELATED PROTEIN BCL-Y, AND METHODS OF USE THEREOF

Publication Number WO/1996/005232
Publication Date 22.02.1996
International Application No. PCT/US1995/010103
International Filing Date 09.08.1995
Chapter 2 Demand Filed 29.02.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/4702
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4702Regulators; Modulating activity
Applicants
  • IMMUNOGEN, INC. [US/US]; 148 Sidney Street Cambridge, MA 02139, US (AllExceptUS)
  • CHITTENDEN, Thomas, D. [US/US]; US (UsOnly)
Inventors
  • CHITTENDEN, Thomas, D.; US
Agents
  • WIXON, Henry, N. ; Hale and Dorr 1455 Pennsylvania Avenue, N.W. Washington, DC 20004, US
Priority Data
08/287,42709.08.1994US
08/321,07111.10.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) APOPTOSIS RELATED PROTEIN BCL-Y, AND METHODS OF USE THEREOF
(FR) PROTEINE Bcl-Y LIE A L'APOPTOSE ET SES PROCEDES D'UTILISATION
Abstract
(EN)
The present invention is directed to an isolated Bcl-Y protein, nucleotide sequences coding for and regulating expression of the protein, antibodies directed against the protein, and recombinant vectors and host cells containing the genetic sequences coding for and regulating the expression of the protein sequence. The invention is also directed to genomic DNA, cDNA, and RNA encoding the Bcl-Y protein sequence and to corresponding antisense RNA sequences. Antibodies can be used to detect Bcl-Y in biological specimens, including, for example, human tissue samples. The present invention is further directed to methods of treating degenerative disorders characterized in inappropriate cell proliferation or inappropriate cell death. The present invention is further directed to methods for diagnosing degenerative disorders characterized in inappropriate cell proliferation or inappropriate cell death, as well as methods for monitoring the progress of such degenerative disorders.
(FR)
L'invention concerne une protéine qu'on a isolée, Bcl-Y, les séquences nucléotidiques codant pour cette protéine et régulant son expression, des anticorps dirigés contre cette protéine, et des vecteurs et cellules hôtes recombinés contenant les séquences génétiques codant pour la séquence protéique et régulant son expression. L'invention concerne aussi l'ADN, l'ADNc et l'ARN génomiques codant la séquence protéique Bcl-Y, et concerne les séquences d'ARN antisens correspondantes. On peut utiliser des anticorps pour détecter Bcl-Y dans des spécimens biologiques, dont, par exemple, des échantillons de tissus humains. L'invention concerne de plus des procédés de traitement de troubles dégénératifs caractérisés par une prolifération ou une mort cellulaire inappropriée. L'invention concerne enfin des procédés de diagnostic desdits troubles dégénératifs ainsi que des procédés permettant de surveiller l'évolution de ces troubles.
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