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1. WO1996005223 - ABUNDANT EXTRACELLULAR PRODUCTS AND METHODS FOR THEIR PRODUCTION AND USE

Publication Number WO/1996/005223
Publication Date 22.02.1996
International Application No. PCT/US1995/002373
International Filing Date 24.02.1995
Chapter 2 Demand Filed 12.03.1996
IPC
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/35 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
35from Mycobacteriaceae (F)
CPC
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/35
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
35from Mycobacteriaceae (F)
Applicants
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 21st floor 300 Lakeside Drive Oakland, CA 94612-3350, US
Inventors
  • HORWITZ, Marcus, A.; US
Agents
  • MACLEAN, Kurt, A.; Poms, Smith, Lande & Rose Suite 3800 2029 Century Park East Los Angeles, CA 90067, US
Priority Data
289,66712.08.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ABUNDANT EXTRACELLULAR PRODUCTS AND METHODS FOR THEIR PRODUCTION AND USE
(FR) PRODUITS EXTRACELLULAIRES ABONDANTS, PROCEDES POUR LES PRODUIRE ET LEUR UTILISATION
Abstract
(EN)
Vaccines based on combinations of majorly abundant extracellular products of pathogens and methods for their use and production are presented. The most prevalent or majorly abundant extracellular products of a target pathogen are selected irrespective of their absolute molecular immunogenicity and used as vaccines to stimulate a protective immune response in mammalian hosts against subsequent infection by the target pathogen. The majorly abundant extracellular products may be characterized and distinguished by their respective N-terminal amino acid sequences. As the vaccines may comprise different combinations of the extracellular products, a broad range effective immunotherapeutic compositions are provided by the present invention. In addition to other infectious agents, the vaccines so produced can be used to stimulate an effective immune response against intracellular pathogens and in particular $i(Mycobacterium tuberculosis).
(FR)
L'invention concerne des vaccins basés sur des combinaisons de produits extracellulaires majoritaires de pathogènes et des procédés pour les produire et les utiliser. On choisit les produits extracellulaires prévalants ou majoritaires d'un pathogène particulier, indépendamment de leur immunogénicité moléculaire absolue et on les utilise comme vaccins pour stimuler la réponse immune chez des hôtes mammifères contre une infection subséquente par le pathogène particulier considéré. Les produits extracellulaires majoritaires peuvent être caractérisés et identifiés par leurs séquences respectives d'acides aminés aux extrémités N-terminales. Comme les vaccins peuvent comporter différentes combinaisons de produits extracellulaires, l'invention permet une gamme étendue de protection immunothérapeutique efficace. En plus de $i(Mycobacterium tuberculosis), les vaccins ainsi produits peuvent être utilisés pour stimuler efficacement la réponse immune contre d'autres agents infectieux intracellulaires.
Also published as
Latest bibliographic data on file with the International Bureau