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1. WO1996005219 - PURIFIED FORM OF STREPTOGRAMINES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT

Publication Number WO/1996/005219
Publication Date 22.02.1996
International Application No. PCT/FR1994/001006
International Filing Date 12.08.1994
Chapter 2 Demand Filed 08.02.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 5/078 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
078the first amino acid being heterocyclic, e.g. Pro, His, Trp
C07K 7/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 5/06139
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
06139with the first amino acid being heterocyclic
C07K 5/06182
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
06139with the first amino acid being heterocyclic
06182and Pristinamycin II; Derivatives thereof
C07K 7/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
Applicants
  • RHONE-POULENC RORER S.A. [FR/FR]; 20, avenue Raymond-Aron F-92160 Antony, FR
Inventors
  • ANGER, Pascal; FR
  • BONNAVAUD, Bertrand; FR
  • CALLET, Alain; FR
  • LEFEVRE, Patrick; FR
Agents
  • LOBJOIS, Françoise; Rhône-Poulenc Rorer S.A. Direction Brevets 20, avenue Raymond-Aron F-92165 Antony Cédex, FR
Priority Data
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) PURIFIED FORM OF STREPTOGRAMINES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT
(FR) FORME PURIFIEE DE STREPTOGRAMINES, SA PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LA CONTIENNENT
Abstract
(EN)
Purified form of streptogramines comprised of the association of one or a plurality of components of the group B of streptogramines having general formula (I), wherein A1 is a radical having general formula (1a) or (Ia') wherein R' is H or OH and Y is H, a methylamino radical or a dimethylamino radical, R is an ethyl radical or when R' is H, R can also be -CH3, and R1 and R2 are H, or A1 is a radical having formula (Ib), R is an isobutyl radical and R1 is OH and R2 is -CH3, and one or a plurality of minor components of the group A of streptogramines having general formula (II) wherein R' is H or a methyl or ethyl radical, in the form of a cocrystallisate, coprecipitate or physical mixture of powders.
(FR)
Forme purifiée de streptogramines constituée d'une association d'une ou plusieurs composantes du groupe B des streptogramines, de formule générale (I), dans laquelle A1 est un radical de formule générale (1a) ou (Ia') pour lequel R' est H ou OH et Y est H, un rdical méthylamino ou un radical diméthylamino, R est un radical éthyle ou lorsque R' est H, R peut également représenter -CH3, et R1 et R2 sont H, ou bien, A1 est un radical de formule (Ib), R est un radical isobutyle, et R1 est OH et R2 est -CH3, et d'une ou plusieurs composantes minoritaires du groupe A des streptogramines, de formule générale (II) dans laquelle R' est H ou un radical méthyle ou éthyle, à l'état de cocristallisat, de coprécipitat ou de mélange physique des poudres.
Also published as
Latest bibliographic data on file with the International Bureau