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1. WO1996005217 - PHARMACEUTICAL COMPOSITIONS CONTAINING ESTRA-1,3,5(10)-TRIENE DERIVATIVES

Publication Number WO/1996/005217
Publication Date 22.02.1996
International Application No. PCT/DE1995/000879
International Filing Date 03.07.1995
Chapter 2 Demand Filed 19.12.1995
IPC
A61K 31/565 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
565not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
A61K 31/58 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
58containing heterocyclic rings, e.g. aldosterone, danazol, stanozolol, pancuronium, digitogenin
C07J 41/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
41Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
C07J 43/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
43Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopentahydrophenanthrene skeleton
C07J 53/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
53Steroids in which the cyclopentahydrophenanthrene skeleton has been modified by condensation with carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms
CPC
A61K 31/565
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
565not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
A61K 31/58
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
58containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
A61P 13/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
08of the prostate
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
A61P 15/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
12for climacteric disorders
A61P 15/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
18Feminine contraceptives
Applicants
  • JENAPHARM GMBH [DE/DE]; Otto-Schott-Strasse 15 D-07745 Jena, DE (AllExceptUS)
  • SIEMANN, Christel [DE/DE]; DE (UsOnly)
  • ELGER, Walter [DE/DE]; DE (UsOnly)
  • SCHWARZ, Sigfrid [DE/DE]; DE (UsOnly)
  • REDDERSEN, Gudrun [DE/DE]; DE (UsOnly)
  • SCHNEIDER, Birgitt [DE/DE]; DE (UsOnly)
Inventors
  • ELGER, Walter; DE
  • SCHWARZ, Sigfrid; DE
  • REDDERSEN, Gudrun; DE
  • SCHNEIDER, Birgitt; DE
  • SIEMANN, Hans-Joachim; null
Agents
  • WABLAT, Wolfgang; Potsdamer Chaussee 48 D-14129 Berlin, DE
Priority Data
P 44 29 398.409.08.1994DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) PHARMAZEUTISCHE ZUSAMMENSETZUNGEN MIT ESTRA-1,3,5(10)-TRIEN-DERIVATEN
(EN) PHARMACEUTICAL COMPOSITIONS CONTAINING ESTRA-1,3,5(10)-TRIENE DERIVATIVES
(FR) COMPOSITIONS PHARMACEUTIQUES COMPRENANT DES DERIVES ESTRA-1,3,5(10)-TRIENE
Abstract
(DE)
Die Erfindung betrifft pharmazeutische Zusammensetzungen, welche als Wirkstoffe Estra-1,3,5(10)-trien-Derivate enthalten, die am C-Atom 3 eine R-SO2-O-Gruppe tragen, worin R eine R1R2N-Gruppe ist, worin R1 und R2 unabhängig voneinander ein Wasserstoffatom, einen C1-C5-Alkylrest oder zusammen mit dem N-Atom einen Polymethyleniminorest mit 4 bis 6 C-Atomen oder einen Morpholinorest bedeuten. Die erfindungsgemäßen Zusammensetzungen sind zur hormonalen Kontrazeption und in der klimakterischen Hormon-Replacement-Therapie (HRT) sowie zur Behandlung gynäkologischer und andrologischer Krankheitsbilder geeignet. Daher weisen die erfindungsgemäßen Zusammensetzungen nur eine geringe hepatische Estrogenität auf.
(EN)
The invention concerns pharmaceutical compositions containing as the active substance estra-1,3,5(10)-triene derivatives with an R-SO2-O- group on the 3 C-atom, R being an R1R2N- group in which R1 and R2, independently of each other, are a hydrogen atom, an alkyl group with 1 to 5 C-atoms or, together with the N-atom, a polymethyleneimino group with 4 to 6 C-atoms or a morpholino group. The compounds described are suitable for use in hormonal contraception and in climacteric hormone-replacement therapy (HRT), as well as in the treatment of gynaecological and andrological conditions. The compounds described thus only have a low hepatic oestrogenicity.
(FR)
L'invention concerne des compositions pharmaceutiques qui contiennent pour principes actifs des dérivés estra-1,3,5(10)-triène présentant un groupe R-SO2-O-sur l'atome de C en position 3, où R désigne un groupe R1R2N-, dans lequel R1 et R2 désignent indépendamment l'un de l'autre un atome d'hydrogène, un reste alkyle C1-C5 ou conjointement avec l'atome de N, un reste polyméthylènimino ayant entre 4 et 6 atomes de C ou un reste morpholino. Ces compositions s'utilisent dans la contraception hormonale et dans l'hormonothérapie climatérique de substitution, ainsi que dans le traitement de syndromes gynécologiques et andrologiques. Ces compositions ne présentent de ce fait qu'une ÷strogénicité hépatique réduite.
Also published as
CZPV1997-273
NO19970569
RO97-00264
SK16297
SK199700162
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