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1. WO1996005211 - GANGLIOSIDE GM3 ANALOG HAVING SIALIC ACID RESIDUE FLUORINATED AT THE 9-POSITION AND INTERMEDIATE THEREFOR

Publication Number WO/1996/005211
Publication Date 22.02.1996
International Application No. PCT/JP1995/001598
International Filing Date 10.08.1995
IPC
C07H 15/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
02Acyclic radicals, not substituted by cyclic structures
04attached to an oxygen atom of a saccharide radical
10containing unsaturated carbon-to-carbon bonds
CPC
C07H 15/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
02Acyclic radicals, not substituted by cyclic structures
04attached to an oxygen atom of the saccharide radical
10containing unsaturated carbon-to-carbon bonds
Applicants
  • DAIKIN INDUSTRIES, LTD. [JP/JP]; Umeda Centre Building 4-12, Nakazaki-nishi 2-chome Kita-ku Osaka-shi Osaka 530-0015, JP (AllExceptUS)
  • IIDA, Takao [JP/JP]; JP (UsOnly)
  • OHIRA, Yutaka [JP/JP]; JP (UsOnly)
Inventors
  • IIDA, Takao; JP
  • OHIRA, Yutaka; JP
Agents
  • AOYAMA, Tamotsu ; Aoyama & Partners IMP Building 3-7, Shiromi 1-chome Chuo-ku, Osaka-shi Osaka 540, JP
Priority Data
6/19248616.08.1994JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) GANGLIOSIDE GM3 ANALOG HAVING SIALIC ACID RESIDUE FLUORINATED AT THE 9-POSITION AND INTERMEDIATE THEREFOR
(FR) ANALOGUE DE GANGLIOSIDE GM3 DOTE D'UN RESIDU D'ACIDE SIALIQUE FLUORE EN POSITION 9, ET INTERMEDIAIRE NECESSAIRE
Abstract
(EN)
A ganglioside GM3 analog having the sialic acid residue fluorinated at the 9-position, represented by general formula (I), and an intermediate therefor, wherein R represents lower aliphatic acyl; R1 represents hydrogen or lower alkyl; R2 through R5 represent each independently hydrogen, lower aliphatic acyl or aromatic acyl; R11 represents linear or branched, saturated or unsaturated C1-C30 aliphatic hydrocarbyl; and n represents an integer of 0 to 20. It is useful as medicines such as an inhibitor for influenza virus and an inhibitor for cancer cell growth or metastasis.
(FR)
On décrit un analogue de ganglioside GM3, doté d'un résidu d'acide sialique fluoré en position 9, représenté par la formule générale (I), ainsi qu'un de ses intermédiaires, où R représente acyle aliphatique inférieur; R1 représente hydrogène ou alkyle inférieur, R2 à R5 représentent chacun indépendamment hydrogène, acyle aliphatique inférieur ou acyle aromatique; R11 représente C1-C30 hydrocarbyle aliphatique saturé ou non, droit ou ramifié; et n représente un nombre entier de 0 à 20. Cet analogue est un médicament utile pour inhiber le virus de la grippe et la croissance ou les métastases des cellules cancéreuses.
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