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1. WO1996005202 - IMIDAZOQUINOLINE DERIVATIVE

Publication Number WO/1996/005202
Publication Date 22.02.1996
International Application No. PCT/JP1995/001621
International Filing Date 14.08.1995
Chapter 2 Demand Filed 13.03.1996
IPC
C07D 471/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • NIPPON HYPOX LABORATORIES INC. [JP/JP]; 1759, Matsugaya Hachioji-shi Tokyo 192-03, JP (AllExceptUS)
  • NIIRO, Yasunori [JP/JP]; JP (UsOnly)
  • UEDA, Hiroki [JP/JP]; JP (UsOnly)
  • SATOH, Toshio [JP/JP]; JP (UsOnly)
  • MATSUMOTO, Hitoshi [JP/JP]; JP (UsOnly)
Inventors
  • NIIRO, Yasunori; JP
  • UEDA, Hiroki; JP
  • SATOH, Toshio; JP
  • MATSUMOTO, Hitoshi; JP
Agents
  • NAKAMURA, Shizuo ; Kumakiri Building, 2nd floor 25-12, Higashi-Ueno 1-chome Taito-ku Tokyo 110, JP
Priority Data
6/19336117.08.1994JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) IMIDAZOQUINOLINE DERIVATIVE
(FR) DERIVE DE L'IMIDAZOQUINOLEINE
Abstract
(EN)
An imidazoquinoline derivative represented by general formula (I) or a pharmacologically acceptable salt thereof (wherein each substituent is as defined in the specification). They have at least two types of pharmacological effects including those of inhibiting lipid peroxidation and platelet agglutination and opposing the actions of histamine and bradykinin and are efficacious for the treatment or prevention of various thromboembolic diseases, transient ischemic diseases such as coronary vascular infarction and cerebral infarction, arteriosclerosis, and reflow disturbance occurring after the recovery from the ischemic conditions, thus being useful as a remedy or preventive for these diseases.
(FR)
Dérivé de l'imidazoquinoléine représenté par la formule générale (I), ou son sel pharmacologiquement acceptable, formule dans laquelle chaque substituant se présente tel qu'il est précisé dans la description. Ces substances ont au moins deux sortes d'effets pharmacologiques, notamment d'inhiber la peroxydation lipidique et l'agglutination plaquettaire et de combattre l'action de l'histamine et de la bradykinine. Elles sont efficaces pour le traitement ou la prévention de diverses maladies thromboemboliques, d'accès ischémiques transitoires comme l'infarctus du myocarde et l'infarctus cérébral, de l'artériosclérose, et en cas de troubles dus aux reperfusions survenant après des affections ischémiques, et constituent donc des remèdes utiles pour traiter ou prévenir ces maladies.
Also published as
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