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1. WO1996005187 - (4-(3-AMINOMETHYLPHENYL)THIAZOL-2-YL)-GUANIDINES AS H2-RECEPTOR ANTAGONISTS

Publication Number WO/1996/005187
Publication Date 22.02.1996
International Application No. PCT/JP1995/001596
International Filing Date 09.08.1995
IPC
C07D 277/48 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
277Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02not condensed with other rings
20having two or three double bonds between ring members or between ring members and non-ring members
32with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38Nitrogen atoms
44Acylated amino or imino radicals
48by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
CPC
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
C07D 277/48
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
277Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02not condensed with other rings
20having two or three double bonds between ring members or between ring members and non-ring members
32with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38Nitrogen atoms
44Acylated amino or imino radicals
48by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
Applicants
  • FUJISAWA PHARMACEUTICAL CO., LTD. [JP/JP]; 4-7, Doshomachi 3-chome Chuo-ku Osaka-shi Osaka 541, JP (AllExceptUS)
  • KATSURA, Yousuke [JP/JP]; JP (UsOnly)
  • TOMISHI, Tetsuo [JP/JP]; JP (UsOnly)
  • NISHINO, Shigetaka [JP/JP]; JP (UsOnly)
  • OHNO, Mitsuko [JP/JP]; JP (UsOnly)
Inventors
  • KATSURA, Yousuke; JP
  • TOMISHI, Tetsuo; JP
  • NISHINO, Shigetaka; JP
  • OHNO, Mitsuko; JP
Agents
  • SEKI, Hideo; Fujisawa Pharmaceutical Co., Ltd. Osaka Factory 1-6, Kashima 2-chome Yodogawa-ku, Osaka-shi Osaka 532, JP
Priority Data
9416459.715.08.1994GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) (4-(3-AMINOMETHYLPHENYL)THIAZOL-2-YL)-GUANIDINES AS H2-RECEPTOR ANTAGONISTS
(FR) (4-(3-AMINOMETHYLPHENYL)THIAZOL-2-YL)GUANIDINES UTILISEES COMME ANTAGONISTES DES RECEPTEURS H2
Abstract
(EN)
New compounds of formula (I), wherein R1 is lower alkoxy, lower alkoxy(lower)alkyl, cyano(lower)alkyl, phenyl, phenyl(lower)alkyl, [2-(lower)alkoxyphenyl] (lower)alkyl, diphenyl(lower)alkyl, phenoxy(lower)alkyl, phenyl(lower)alkoxy(lower)alkyl, cyclo(lower)alkenyl(lower)alkyl, protected amino(lower)alkyl or adamantyloxy(lower)alkyl, and R2 is hydrogen, lower alkanoyl or carbamoyl, and a pharmaceutically acceptable salt thereof which are useful as a medicament.
(FR)
De nouveaux composés, ou un de leurs sels pharmacologiquement acceptables, sont utiles comme médicaments et correspondent à la formule (I), où R1 représente alcoxy inférieur, alcoxy inférieur alkyle(inférieur), cyanoalkyle(inférieur), phényle, phénylalkyle(inférieur), [2-alcoxyphényle(inférieur)]alkyle(inférieur), diphénylalkyle(inférieur), phénoxyalkyle(inférieur), phényl(inférieur)alcoxy(inférieur)alkyle, cycloalcényle(inférieur)alkyle(inférieur), aminoalkyle(inférieur)protégé ou adamantyloxyalkyle(inférieur), et R2 représente hydrogène, ou alcanoyle ou carbamoyle inférieur.
Also published as
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