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1. WO1996005186 - THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE

Publication Number WO/1996/005186
Publication Date 22.02.1996
International Application No. PCT/JP1995/001579
International Filing Date 09.08.1995
Chapter 2 Demand Filed 23.02.1996
IPC
C07D 277/34 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
277Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02not condensed with other rings
20having two or three double bonds between ring members or between ring members and non-ring members
32with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
34Oxygen atoms
C07D 417/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
C07D 277/34
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
277Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02not condensed with other rings
20having two or three double bonds between ring members or between ring members and non-ring members
32with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
34Oxygen atoms
C07D 417/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • TAKEDA CHEMICAL INDUSTRIES, LTD. [JP/JP]; 1-1, Doshomachi 4-chome Chuo-ku Osaka-shi Osaka 541, JP (AllExceptUS)
  • SOHDA, Takashi [JP/JP]; JP (UsOnly)
  • ODAKA, Hiroyuki [JP/JP]; JP (UsOnly)
  • MOMOSE, Yu [JP/JP]; JP (UsOnly)
Inventors
  • SOHDA, Takashi; JP
  • ODAKA, Hiroyuki; JP
  • MOMOSE, Yu; JP
Agents
  • AOYAMA, Tamotsu ; Aoyama & Partners IMP Building 3-7, Shiromi 1-chome Chuo-ku, Osaka-shi Osaka 540, JP
Priority Data
6/18861110.08.1994JP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE
(FR) DERIVES DE LA THIAZOLIDINDIONE, LEUR PROCEDE D'OBTENTION ET LEURS UTILISATIONS
Abstract
(EN)
A 2,4-thiazolidinedione derivative of formula (I), wherein R is an optionally substituted hydrocarbon group or heterocyclic group which may be attached through a hydrocarbon chain; n is 0 or 1; X is CH or N; Y is a bivalent hydrocarbon group; R1 and R2 are the same or different and are a hydrogen atom, a halogen atom, an optionally substituted hydroxyl group or an optionally substituted hydrocarbon group, and either R1 or R2 and a part of Y may be linked together to form a ring; and L and M are a hydrogen atom, or L and M are linked together to form a bond; or a salt thereof. A pharmaceutical composition comprising the compound (I) and a process for producing the compound (I) are also provided.
(FR)
Dérivés de la 2,4-thiazolidinedione de formule (I) où R est un groupe hydrocarbure facultativement substitué ou un groupe hétérocyclique pouvant être fixé par l'intermédiaire d'une chaîne hydrocarbure; n est 0 ou 1; X est CH ou N; Y est un groupe hydrocarbure bivalent; R1 et R2 sont identiques ou différents et représentent un atome d'hydrogène, un atome d'halogène, un groupe hydroxyle facultativement substitué ou un groupe hydrocarbure facultativement substitué, et dans lequel R1 ou R2 ou une partie de Y peuvent se fixer ensemble pour former une liaison; ou l'un de ses sels. Préparation pharmaceutique contenant le dérivé (I) et procédé d'obtention de ce dernier.
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