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1. WO1996005178 - SYNTHESIS OF BENZODIAZEPINES

Publication Number WO/1996/005178
Publication Date 22.02.1996
International Application No. PCT/US1995/009376
International Filing Date 26.07.1995
IPC
C07D 243/24 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
243Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
06having the nitrogen atoms in positions 1 and 4
10condensed with carbocyclic rings or ring systems
141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
16substituted in position 5 by aryl radicals
18substituted in position 2 by nitrogen, oxygen or sulfur atoms
24Oxygen atoms
CPC
C07D 243/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
243Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
06having the nitrogen atoms in positions 1,4
10condensed with carbocyclic rings or ring systems
141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
16substituted in position 5 by aryl radicals
18substituted in position 2 by nitrogen, oxygen or sulfur atoms
24Oxygen atoms
Y10T 428/216
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
428Stock material or miscellaneous articles
21Circular sheet or circular blank
216Ornamental, decorative, pattern, or indicia
Y10T 428/218
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
428Stock material or miscellaneous articles
21Circular sheet or circular blank
218Aperture containing
Y10T 428/24355
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
428Stock material or miscellaneous articles
24Structurally defined web or sheet [e.g., overall dimension, etc.]
24355Continuous and nonuniform or irregular surface on layer or component [e.g., roofing, etc.]
Y10T 428/24479
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
428Stock material or miscellaneous articles
24Structurally defined web or sheet [e.g., overall dimension, etc.]
24479including variation in thickness
Applicants
  • IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. [US/US]; 214 O & L Ames, IA 50011-3021, US
Inventors
  • KRAUS, George, A.; US
Agents
  • RAASCH, Kevin, W.; Schwegman, Lundberg & Woessner 3500 IDS Center 80 South Eighth Street Minneapolis, MN 55402, US
Priority Data
08/286,92908.08.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SYNTHESIS OF BENZODIAZEPINES
(FR) SYNTHESE DE BENZODIAZEPINES
Abstract
(EN)
A general method is provided for the synthesis of substituted 2,3-dihydro-5-phenyl-1H-1,4-benzodiazepines by the reaction of bis-triflated-2,5-dihydroxy benzophenones with 1,2-bisaminoethanes, followed by displacement of the 7-trifloxy group.
(FR)
Cette invention se rapporte à un procédé général pour réaliser la synthèse de 2,3-dihydro-5-phényl-1H-1,4-benzodiazépines substituées, en faisant réagir des benzophénones 2,5-dihydroxy bis-triflatées avec des 1,2-bis-aminoéthanes, puis en déplaçant le groupe 7-trifloxy.
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