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1. WO1996004953 - ORALLY ADMINISTRABLE DELIVERY DEVICE

Publication Number WO/1996/004953
Publication Date 22.02.1996
International Application No. PCT/IE1995/000039
International Filing Date 04.08.1995
Chapter 2 Demand Filed 19.01.1996
IPC
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61M 5/142 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
5Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
142Pressure infusion, e.g. using pumps
A61M 5/145 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
5Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
142Pressure infusion, e.g. using pumps
145using pressurised reservoirs, e.g. by means of pistons
A61M 31/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
31Devices for introducing or retaining media, e.g. remedies, in cavities of the body
CPC
A61K 9/0009
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
0009involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
A61M 2005/14204
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
5Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
142Pressure infusion, e.g. using pumps
14204with gas-producing electrochemical cell
A61M 31/002
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
31Devices for introducing or retaining media, e.g. remedies, in cavities of the body
002Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
A61M 5/14593
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
5Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
142Pressure infusion, e.g. using pumps
145using pressurised reservoirs, e.g. pressurised by means of pistons
14586pressurised by means of a flexible diaphragm
14593the diaphragm being actuated by fluid pressure
Applicants
  • ELAN MEDICAL TECHNOLOGIES LIMITED [IE/IE]; Monksland Industrial Estate Athlone County Westmeath, IE (AllExceptUS)
  • GROSS, Joseph [IL/IE]; IE (UsOnly)
  • KELLY, John, Gerard [GB/IE]; IE (UsOnly)
Inventors
  • GROSS, Joseph; IE
  • KELLY, John, Gerard; IE
Agents
  • ANNE RYAN & CO.; 60 Northumberland Road Ballsbridge Dublin 4, IE
Priority Data
94064315.08.1994IE
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ORALLY ADMINISTRABLE DELIVERY DEVICE
(FR) DISPOSITIF D'ADMINISTRATION INTRODUIT PAR LA BOUCHE
Abstract
(EN)
An orally administrable delivery device (10) comprising a housing (11) with walls of a water-permeable material and having a first chamber (13) adapted to receive an active ingredient, an orifice (15) through which the active ingredient is expelled from the housing (10) under pressure in a liquid form and a second chamber (14) containing two spaced-apart electrodes (16, 17) which form part of an electric circuit which is closed upon ingress of an aqueous ionic solution to the second chamber (14), such that a potential difference is set up between the electrodes (16, 17) and a current flows through the circuit resulting in the generation of a gas at electrode (16), the gas once generated acting on a displaceable membrane (12) to compress the first chamber (13) and expel the active ingredient through the orifice (15) for progressive delivery to the gastrointestinal tract. The electrode (16) forms part of an electric circuit which is closed by the ingress of an electrolyte (the aqueous solution), the circuit allowing controlled generation of gas and, thereby, controlled delivery of the active ingredient to the gastrointestinal tract.
(FR)
Un dispositif d'administration (10) introduit par la bouche a un logement (11) avec des parois faites en une substance perméable à l'eau. Le logement (11) a une première chambre (13) agencée pour recevoir un ingrédient actif, un orifice (15) par lequel l'ingrédient actif est expulsé du logement (11) par la pression du liquide et une seconde chambre (14) renfermant deux électrodes espacées (16, 17) qui font partie d'un circuit électrique qui est fermé par la pénétration d'une solution aqueuse ionique dans la seconde chambre (14). A ce moment, il s'établit une différence de potentiel entre les électrodes (16, 17) et un courant circule dans le circuit, ce qui aboutit à la production de gaz à l'électrode (16), le gaz généré agissant sur une membrane mobile (12) pour comprimer la première chambre (13) et expulser l'ingrédient actif par l'orifice (15), ce qui assure une administration progressive dans le tractus gastro-intestinal. L'électrode (16) fait partie d'un circuit électrique qui est fermé par la pénétration d'un électrolyte (la solution aqueuse) et le circuit permet une production contrôlée de gaz et donc une administration contrôlée de l'ingrédient actif dans le tractus gastro-intestinal.
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