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1. WO1996004943 - BIOLOGICALLY COMPATIBLE HYDROGEL

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Publication Number WO/1996/004943
Publication Date 22.02.1996
International Application No. PCT/UA1994/000022
International Filing Date 12.08.1994
Chapter 2 Demand Filed 21.11.1995
IPC
A61L 27/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
14Macromolecular materials
16obtained by reactions only involving carbon-to-carbon unsaturated bonds
A61L 27/52 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
50Materials characterised by their function or physical properties
52Hydrogels or hydrocolloids
A61L 31/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles
04Macromolecular materials
A61L 31/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles
14Materials characterised by their function or physical properties
CPC
A61L 2400/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2400Materials characterised by their function or physical properties
06Flowable or injectable implant compositions
A61L 27/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
14Macromolecular materials
16obtained by reactions only involving carbon-to-carbon unsaturated bonds
A61L 27/52
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
50Materials characterised by their function or physical properties ; , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
52Hydrogels or hydrocolloids
A61L 31/048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles ; , e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
04Macromolecular materials
048obtained by reactions only involving carbon-to-carbon unsaturated bonds
A61L 31/145
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles ; , e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
14Materials characterised by their function or physical properties ; , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
145Hydrogels or hydrocolloids
Applicants
  • MALOE VNEDRENCHESKOE PREDPRIYATIE 'INTERFALL' [UA]/[UA] (AllExceptUS)
  • PAVLYK, Boris Ivanovich [UA]/[UA] (UsOnly)
Inventors
  • PAVLYK, Boris Ivanovich
Agents
  • KUTSEVICH, Valery Ljudvikovich
Priority Data
9408672610.08.1994UA
Publication Language Russian (RU)
Filing Language Russian (RU)
Designated States
Title
(EN) BIOLOGICALLY COMPATIBLE HYDROGEL
(FR) HYROGEL BIOCOMPATIBLE
Abstract
(EN)
The proposed biologically compatible hydrogel is intended for use in the correction of cosmetic or functional defects (e.g., of the mammary glands, vocal cords, penis, etc., by endoprosthesis), in the creation of interstitial reservoirs of prolonged-action drugs, or for use as electroconductive immersion mediums and for the permanent packing of sinuses. The proposed hydrogel contains an acrylamide-based polymer obtained using a radical polymerisation initiator in apyrogenic water as the dispersion medium. In order to improve the flexibility, firmness and stability of bulk implants and thus improve their therapeutic and cosmetic effectiveness especially in endoprosthesis, the hydrogel contains cross-linked polyacrylamide obtained using a biologically compatible cross-linking agent, preferably methylene-bis-acrylamide, and preferably using a mixture of ammonium persulphate and tetramethylethylene diamine as the polymerisation initiator. The preferred concentration of this polymer in the hydrogel is between 3.5 and 9 % by weight.
(FR)
L'hydrogel biocompatible de l'invention est destiné à être utilisé dans la correction de défauts d'ordre cosmétique ou fonctionnel (par exemple des glandes mammaires, des cordes vocales, du pénis, etc., par endoprothèse), dans la création de réservoirs intersticiels de médicaments à action prolongée, ou à être utilisé en tant que milieu d'immersion électroconducteur et pour le remplissage permanent de sinus. L'hydrogel proposé contient un polymère à base d'acrylamide obtenu à l'aide d'un initiateur de polymérisation radicalaire dans de l'eau apyrogène en tant que milieu de dispersion. Afin d'améliorer la flexibilité, la fermeté et la stabilité d'implants d'un volume donné, et par conséquent d'améliorer leur efficacité thérapeutique et cosmétique notamment en endoprothèse, l'hydrogel contient un polyacrylamide réticulé obtenu à l'aide d'un agent de réticulation biocompatible, de préférence du méthylène-bis-acrylamide, et de préférence à l'aide d'un mélange de persulfate d'ammonium et de tétraméthyléthylènediamine en tant qu'initiateur de polymérisation. La concentration préférée de ce polymère dans l'hydrogel est comprise entre 3,5 et 9 % en poids.
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