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1. WO1996004934 - RETROVIRAL VECTORS PRODUCED BY PRODUCER CELL LINES RESISTANT TO LYSIS BY HUMAN SERUM

Publication Number WO/1996/004934
Publication Date 22.02.1996
International Application No. PCT/US1995/010496
International Filing Date 17.08.1995
Chapter 2 Demand Filed 16.02.1996
IPC
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C12N 15/867 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
867Retroviral vectors
CPC
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C12N 15/86
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
C12N 2740/13043
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2740Reverse Transcribing RNA Viruses
00011Reverse Transcribing RNA Viruses
10011Retroviridae
13011Gammaretrovirus, e.g. murine leukeamia virus
13041Use of virus, viral particle or viral elements as a vector
13043viral genome or elements thereof as genetic vector
Applicants
  • GENETIC THERAPY INC. [US/US]; 938 Clopper Road Gaithersburg, MD 20878, US
  • INSTITUTE OF CANCER RESEARCH-ROYAL CANCER HOSPITAL [GB/GB]; 17A Onslow Gardens London SW7 3AL, GB
Inventors
  • PENSIERO, Michael; US
  • COLLINS, Mary, K., L.; GB
  • COSSET, Francois-Loic; GB
  • TAKEUCHI, Yasuhiro; GB
  • WEISS, Robin, A.; GB
Agents
  • LILLIE, Raymond, J. ; Carella, Byrne, Bain, Gilfillan, Cecchi, Stewart & Olstein 6 Becker Farm Road Roseland, NJ 07068, US
Priority Data
08/291,76517.08.1994US
08/451,21526.05.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) RETROVIRAL VECTORS PRODUCED BY PRODUCER CELL LINES RESISTANT TO LYSIS BY HUMAN SERUM
(FR) VECTEURS RETROVIRAUX PRODUITS PAR DES LIGNEES DE CELLULES PRODUCTRICES RESISTANTES A LA LYSE PAR LE SERUM HUMAIN
Abstract
(EN)
Retroviral vectors which are resistant to inactivation by human serum. The retroviral vectors are produced in a cell line which is resistant to lysis by human serum, such cell lines including the HOS, Mv-1-Lu, HT1080, TE671, and human 293 cell lines, as well as cell lines derived therefrom. Such retroviral vectors are especially useful as $i(in vivo) gene delivery vehicles.
(FR)
Vecteurs rétroviraux résistant à une inactivation par le sérum humain. Ces vecteurs rétroviraux sont produits dans une lignée cellulaire qui est résistante à la lyse par le sérum humain. Ces lignées cellulaires peuvent être des lignées de cellules HOS, Mv-1-Lu, HT1080, TE671 et des lignées de cellules humaines 293, ainsi que des lignées de cellules qui en sont dérivées. De tels vecteurs rétroviraux sont particulièrement utiles comme véhicules d'apport en gènes $i(in vivo).
Also published as
Latest bibliographic data on file with the International Bureau