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1. WO1996004926 - TWO NON-CONTIGUOUS REGIONS CONTRIBUTE TO NIDOGEN BINDING TO A SINGLE EGF-LIKE MOTIF OF THE LAMININ $g(g)1 CHAIN

Publication Number WO/1996/004926
Publication Date 22.02.1996
International Application No. PCT/US1995/009693
International Filing Date 11.08.1995
Chapter 2 Demand Filed 13.03.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/78 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin (CIG)
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/78
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
Applicants
  • THE UNIVERSITY OF VIRGINIA PATENT FOUNDATION [US/US]; Suite 1-110 The Towers Office Building 1224 West Main Street Charlottesville, VA 22903, US
Inventors
  • FOX, Jay, W.; US
  • TIMPL, Rupert; DE
Agents
  • OBLON, Norman, F. ; Oblon, Spivak, McClelland, Maier & Neustadt, P.C. 4th floor 1755 Jefferson Davis Highway Crystal Square Five Arlington, VA 22202, US
Priority Data
288,72815.08.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TWO NON-CONTIGUOUS REGIONS CONTRIBUTE TO NIDOGEN BINDING TO A SINGLE EGF-LIKE MOTIF OF THE LAMININ $g(g)1 CHAIN
(FR) DEUX REGIONS NON CONTIGUES CONTRIBUANT A LA LIAISON NIDOGENE AVEC UN MOTIF UNIQUE DU TYPE EGF DE LA CHAINE $g(g)1 DE LA LAMININE
Abstract
(EN)
The present invention relates to peptide antagonists which specifically prevent laminin interaction with nidogen. Laminin is a major cell-adhesive and structural protein of basement membranes and other extracellular structures occurring as various isoforms of 600-900 kDa, and contains a single high affinity binding site for the 150 kDa basement membrane protein nidogen. The peptide antagonists of this invention may be applied to in vitro studies of organ development or as therapeutic agents for clinical use.
(FR)
Cette invention concerne des antagonistes de peptides qui empêchent de manière spécifique l'interaction de la laminine avec le nidogène. La laminine est une protéine majeure de structure et d'adhésion cellulaire des membranes basales et d'autres structures extracellulaires se présentant sous diverses isoformes de 600-900 kDa, et contient un seul et unique site de liaison à forte affinité pour le nidogène de protéine de membrane basale à 150 kDa. On peut utiliser les antagonistes de peptides de cette invention dans le cadre des recherches in vitro sur la croissance d'organe ou comme agents thérapeutiques destinés à un usage clinique.
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