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1. WO1996004921 - TNF$g(a)-SECRETION INHIBITOR CONTAINING SYRINGIN OR ITS AGLYCONE

Publication Number WO/1996/004921
Publication Date 22.02.1996
International Application No. PCT/KR1994/000110
International Filing Date 13.08.1994
Chapter 2 Demand Filed 12.03.1996
IPC
A61K 31/09 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
075Ethers or acetals
085having an ether linkage to aromatic ring nuclear carbon
09having two or more such linkages
CPC
A61K 31/09
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
075Ethers or acetals
085having an ether linkage to aromatic ring nuclear carbon
09having two or more such linkages
A61K 31/7034
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034attached to a carbocyclic compound, e.g. phloridzin
Applicants
  • CHUNG, Hong, Keun [KR/KR]; KR
Inventors
  • CHUNG, Hong, Keun; KR
Agents
  • SUH, Jong, Wan; 3rd floor New-Seoul Building 828-8, Yeoksam-dong Kangnam-ku Seoul 135-080, KR
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TNF$g(a)-SECRETION INHIBITOR CONTAINING SYRINGIN OR ITS AGLYCONE
(FR) INHIBITEUR DE LA SECRETION DU TNF$g(a) CONTENANT DE LA SYRINGINE OU SON AGLYCONE
Abstract
(EN)
The present invention relates to a TNF$g(a)-secretion inhibitor, more particularly to a TNF$g(a)-secretion inhibitor containing syringin or syringin aglycone as active ingredient. Syringin or syringin aglycone purified from Fraxinus spp. or Eucommia ulmoides shows TNF$g(a)-secretion inhibiting effect without considerable toxicity. It also shows anti-hypersensitivity effect and anti-inflammatory effect toward autoimmune disease such as uveitis.
(FR)
La présente invention porte sur un inhibiteur de la sécrétion du TNF$g(a), plus spécialement sur une substance inhibitrice de la sécrétion du TNF$g(a), contenant de la syringine ou de l'aglycone de syringine pour principe actif. La syringine ou son aglycone purifiées, extraites d'arbres de l'espèce du frêne et de l'eucommia pseudo-orme, ont une action inhibitrice de la sécrétion du TNF$g(a) sans toxicité significative. Ces substances combattent également l'hypersensibilité et ont une influence anti-inflammatoire en cas de maladie auto-immune comme l'uvéite.
Also published as
Latest bibliographic data on file with the International Bureau