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1. WO1996004909 - USE OF QUINONE AND HYDROQUINONE DERIVATIVES FOR THE TEATMENT OF CACHEXIA

Publication Number WO/1996/004909
Publication Date 22.02.1996
International Application No. PCT/JP1995/001594
International Filing Date 10.08.1995
Chapter 2 Demand Filed 02.12.1995
IPC
A61K 31/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
A61K 31/122 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
122having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
A61K 31/38 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
38having sulfur as a ring hetero atom
A61K 31/381 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
38having sulfur as a ring hetero atom
381having five-membered rings
A61K 31/415 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4151,2-Diazoles
A61K 31/425 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425Thiazoles
CPC
A61K 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
A61K 31/122
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
122having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
A61K 31/38
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
38having sulfur as a ring hetero atom
A61K 31/381
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
38having sulfur as a ring hetero atom
381having five-membered rings
A61K 31/415
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
4151,2-Diazoles
A61K 31/425
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
425Thiazoles
Applicants
  • TAKEDA CHEMICAL INDUSTRIES, LTD. [JP/JP]; 1-1, Doshomachi 4-chome Chuo-ku Osaka-shi Osaka 541, JP (AllExceptUS)
  • TERAO, Shinji [JP/JP]; JP (UsOnly)
  • TISDALE, Michael, John [GB/GB]; GB (UsOnly)
Inventors
  • TERAO, Shinji; JP
  • TISDALE, Michael, John; GB
Agents
  • ASAHINA, Tadao ; Osaka Plant of Takeda Chemical Industries, Ltd. 17-85, Jusohonmachi 2-chome Yodogawa-ku Osaka-shi Osaka 532, JP
  • ELKINGTON AND FIFE; Prospect House 8 Pembroke Road Sevenoaks Kent TN13 1XR, GB
Priority Data
6/19073212.08.1994JP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) USE OF QUINONE AND HYDROQUINONE DERIVATIVES FOR THE TEATMENT OF CACHEXIA
(FR) UTILISATION DE DERIVES DE QUINONE ET D'HYDROQUINONE POUR TRAITER LA CACHEXIE
Abstract
(EN)
A pharmaceutical composition for treating cachexia which contains a compound (I), wherein R1, R2 is H, alkyl, alkoxy, may form -CH=CH-CH=CH-; R3 is H, alkyl; R4 is N-containing heterocyclic; R5 is H, alkyl, hydroxyalkyl, carboxyl; Z is (a), -CH=CH-, (b) or (c); (R0 is H, alkyl); n is 0-12; m is 0-3; k is 0-7, or a salt thereof.
(FR)
Une composition pharmaceutique, destinée à traiter la cachexie, contient un composé de formule (I), ou son sel, où R1 et R2 représentent H, alkyle, alcoxy, ou bien peuvent former -CH=CH-CH=CH-; R3 représente H ou alkyle; R4 représente un groupe hétérocyclique contenant N; R5 représente H, alkyle, hydroxyalkyle ou carboxyle; et Z représente (a), -CH=CH-, (b) ou (c) (où R0 représente H ou alkyle); n vaut de 0 à 12; m vaut de 0 à 3; k vaut de 0 à 7.
Latest bibliographic data on file with the International Bureau