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1. WO1996004905 - PHENOXYPHENYLACETIC ACID DERIVATIVES

Publication Number WO/1996/004905
Publication Date 22.02.1996
International Application No. PCT/US1995/009967
International Filing Date 07.08.1995
Chapter 2 Demand Filed 23.02.1996
IPC
C07C 65/24 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
65Compounds having carboxyl groups bound to carbon atoms of six-membered aromatic rings and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
21containing ether groups, groups, groups, or groups
24polycyclic
C07D 317/60 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
317Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
08having the hetero atoms in positions 1 and 3
44ortho- or peri-condensed with carbocyclic rings or ring systems
46condensed with one six-membered ring
48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
50with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
60Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D 405/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 409/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 13/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
02of urine or of the urinary tract, e.g. urine acidifiers
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
C07C 65/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
65Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
21containing ether groups, groups, groups, or groups
24polycyclic
C07D 317/60
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
317Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
08having the hetero atoms in positions 1 and 3
44ortho- or peri-condensed with carbocyclic rings or ring systems
46condensed with one six-membered ring
48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes unsubstituted on the hetero ring
50with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
60Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D 405/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue Rahway, NJ 07065, US (AllExceptUS)
  • BAGLEY, Scott, W. [US/US]; US (UsOnly)
  • BROTEN, Theodore, P. [US/US]; US (UsOnly)
  • CHAKRAVARTY, Prasun, K. [IN/US]; US (UsOnly)
  • DHANOA, Daljit, S. [CA/US]; US (UsOnly)
  • FITCH, Kenneth, J. [US/US]; US (UsOnly)
  • GREENLEE, William, J. [US/US]; US (UsOnly)
  • KEVIN, Nancy, Jo [US/US]; US (UsOnly)
  • KIECZYKOWSKI, Gerard, R. [US/US]; US (UsOnly)
  • MATTHEWS, Jay, M. [US/US]; US (UsOnly)
  • PETTIBONE, Douglas, J. [US/US]; US (UsOnly)
  • RIVERO, Ralph, A. [US/US]; US (UsOnly)
  • TATA, JAMES, R. [US/US]; US (UsOnly)
  • WALSH, Thomas, F. [US/US]; US (UsOnly)
  • WILLAMS, David, L., Jr. [US/US]; US (UsOnly)
  • TOUPENCE, Richard, B. [US/US]; US (UsOnly)
Inventors
  • BAGLEY, Scott, W.; US
  • BROTEN, Theodore, P.; US
  • CHAKRAVARTY, Prasun, K.; US
  • DHANOA, Daljit, S.; US
  • FITCH, Kenneth, J.; US
  • GREENLEE, William, J.; US
  • KEVIN, Nancy, Jo; US
  • KIECZYKOWSKI, Gerard, R.; US
  • MATTHEWS, Jay, M.; US
  • PETTIBONE, Douglas, J.; US
  • RIVERO, Ralph, A.; US
  • TATA, JAMES, R.; US
  • WALSH, Thomas, F.; US
  • WILLAMS, David, L., Jr.; US
  • TOUPENCE, Richard, B.; US
Common Representative
  • MERCK & CO., INC.; 126 East Lincoln Avenue Rahway, NJ 07065, US
Priority Data
287,37408.08.1994US
294,23222.08.1994US
473,17207.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PHENOXYPHENYLACETIC ACID DERIVATIVES
(FR) DERIVES DE L'ACIDE PHENOXYPHENYLACETIQUE
Abstract
(EN)
Phenoxyphenylacetic acids and derivatives of general structural formula (I) have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endotoxic shock, benign prostatic hyperplasia, inflammatory diseases including Raynaud's disease and asthma.
(FR)
Acide phénoxyphénylacétique et ses dérivés de formule générale (I) présentant une activité antagoniste de l'endothéline, et s'avérant utiles dans le traitement des troubles cardio-vasculaires tels que l'hypertension, l'insuffisance rénale postischémique, les angiospasmes, les ischémies cérébrales et coronarienne, l'infarctus du myocarde, le choc endotoxique, l'adénome prostatique, certains troubles inflammatoires dont la maladie de Raynaud et l'asthme.
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