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1. WO1996004891 - FORMULATION AND USE OF CAROTENOIDS IN TREATMENT OF CANCER

Publication Number WO/1996/004891
Publication Date 22.02.1996
International Application No. PCT/US1995/010044
International Filing Date 08.08.1995
Chapter 2 Demand Filed 27.02.1996
IPC
A61K 9/127 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A61K 31/203 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
20having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
203Retinoic acids
CPC
A61K 31/203
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
20having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
203Retinoic acids ; Salts thereof
A61K 9/127
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
Applicants
  • BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 201 W. 7th Street Austin, TX 78701, US
  • ARGUS PHARMACEUTICALS, INC. [US/US]; 3400 Research Forest Drive The Woodlands, TX 77381, US
Inventors
  • MEHTA, Kapil; US
  • PEREZ-SOLER, Roman; US
  • LOPEZ-BERESTEIN, Gabriel; US
  • LENK, Robert, P.; US
  • HAYMAN, Alan, C.; US
Agents
  • GOODMAN, Kenneth, D. ; Arnold, White & Durkee Suite 400 750 Bering Drive Houston, TX 77057, US
Priority Data
08/286,92808.08.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) FORMULATION AND USE OF CAROTENOIDS IN TREATMENT OF CANCER
(FR) PREPARATION A BASE DE CAROTENOIDES ET LEUR UTILISATION POUR LE TRAITEMENT DU CANCER
Abstract
(EN)
A reduced-toxicity formulation of carotenoids is disclosed which is stable in an aqueous environment. The formulation includes a carotenoid, lipid carrier particles (such as liposomes), and an intercalation promoter agent (such as a triglyceride), which causes the carotenoid to be substantially uniformly distributed with the lipid in the lipid carrier particles. The molar ratio of carotenoid to lipid is greater than about 1:10. Also disclosed is a method of inhibiting the growth of cancer cells, which comprises administering to a living subject a therapeutically effective amount of a composition as described above.
(FR)
Préparation à base de caroténoïdes à toxicité réduite, stable en milieu aqueux, comportant un caroténoïde, des particules d'excipient lipidique, (par exemple des liposomes) et un promoteur d'intercalation (par exemple un triglycéride). Le caroténoïde se trouve ainsi réparti sensiblement uniformément avec le lipide dans les particules d'excipient lipidique. Le rapport molaire caroténoïde/lipide est supérieur à environ 1/10. Est également présentée une méthode d'inhibition de la croissance des cellules cancéreuses consistant à administrer à un sujet vivant une dose thérapeutique efficace de ladite préparation.
Also published as
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