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1. WO1996004844 - A METHOD FOR QUANTITATION OF BORON CONCENTRATION BY MAGNETIC RESONANCE IMAGING

Publication Number WO/1996/004844
Publication Date 22.02.1996
International Application No. PCT/US1995/010191
International Filing Date 11.08.1995
Chapter 2 Demand Filed 11.03.1996
IPC
G01R 33/28 2006.01
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
28Details of apparatus provided for in groups G01R33/44-G01R33/6496
G01R 33/465 2006.01
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
44using nuclear magnetic resonance
46NMR spectroscopy
465applied to biological material, e.g. in vitro testing
G01R 33/563 2006.01
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
44using nuclear magnetic resonance
48NMR imaging systems
54Signal processing systems, e.g. using pulse sequences
56Image enhancement or correction, e.g. subtraction or averaging techniques
563of moving material, e.g. flow-contrast angiography
CPC
G01R 33/443
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
44using nuclear magnetic resonance [NMR]
443Assessment of an electric or a magnetic field, e.g. spatial mapping, determination of a B0 drift or dosimetry
G01R 33/465
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
44using nuclear magnetic resonance [NMR]
46NMR spectroscopy
465applied to biological material, e.g. in vitro testing
G01R 33/563
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
44using nuclear magnetic resonance [NMR]
48NMR imaging systems
54Signal processing systems, e.g. using pulse sequences ; , Generation or control of pulse sequences
56Image enhancement or correction, e.g. subtraction or averaging techniques ; , e.g. improvement of signal-to-noise ratio and resolution
563of moving material, e.g. flow contrast angiography
G01R 33/58
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
44using nuclear magnetic resonance [NMR]
48NMR imaging systems
58Calibration of imaging systems, e.g. using test probes ; , Phantoms; Calibration objects or fiducial markers such as active or passive RF coils surrounding an MR active material
Applicants
  • UNIVERSITY OF UTAH RESEARCH FOUNDATION [US/US]; 210 Park Building Salt Lake City, UT 84112, US
Inventors
  • BRADSHAW, Kenneth, M.; US
  • GLOVER, Gary, H.; US
  • HADLEY, J., Rock; US
  • SCHWEIZER, Martin, P.; US
Agents
  • BOND, Laurence, B. ; Trask, Britt & Rossa P.O. Box 2550 Salt Lake City, UT 84110, US
Priority Data
289,06611.08.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) A METHOD FOR QUANTITATION OF BORON CONCENTRATION BY MAGNETIC RESONANCE IMAGING
(FR) PROCEDE PERMETTANT DE QUANTIFIER LA CONCENTRATION DE BORE PAR IMAGERIE PAR RESONANCE MAGNETIQUE
Abstract
(EN)
A magnetic resonance sensitive (MRS) element, notably boron (B), is compounded in a carrier, such as borocaptate sodium (22). A subject, typically a patient (21) with a brain tumor (24), is positioned in the imaging field of a magnetic resonance imaging machine, along with a reference (38) containing a known concentration of the MRS element. The magnetic resonance imaging machine is operated to produce a signal encoded by a reconstruction method that takes data immediately following the transverse RF pulse. The data is reconstructed to provide, for example, a subject image and a reference image. The subject image is calibrated from the reference image to derive a data matrix relating the concentration of the MRS element in the subject to locations within the subject. The data matrix may then be displayed as an image or downloaded to a computer for controlling radiation dosage during neutron therapy.
(FR)
Un élément sensible à la résonance magnétique, notamment du bore ('B') est combiné à un véhicule, tel que du sodium de boracaptate (22). Un sujet, généralement un patient (21) présentant une tumeur au cerveau (24) est positionné dans le champ d'imagerie de l'appareil d'imagerie par résonance magnétique, avec une référence (38) contenant une concentration connue de l'élément sensible à la résonance magnétique. L'appareil est actionné pour produire un signal codé par un procédé de reconstitution qui prélève les données immédiatement après l'impulsion HF transversale. Les données sont reconstituées, par exemple, pour fournir une image du sujet et une image de référence. L'image du sujet est étalonnée à partir de l'image de référence pour produire une matrice de données concernant la concentration de l'élément sensible à la résonance magnétique à certains emplacements chez le patient. La matrice de données peut alors être visualisée sous forme d'image ou téléchargée vers un ordinateur pour commander le dosage des rayonnements pendant la thérapie par neutrons.
Also published as
Latest bibliographic data on file with the International Bureau