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1. WO1996004790 - DNA ENCODING A HUMAN BETAINE/GABA TRANSPORTER AND USES THEREOF

Publication Number WO/1996/004790
Publication Date 22.02.1996
International Application No. PCT/US1995/010579
International Filing Date 16.08.1995
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
CPC
A01K 2217/05
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
05Animals comprising random inserted nucleic acids (transgenic)
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
Applicants
  • SYNAPTIC PHARMACEUTICAL CORPORATION [US/US]; 215 College Road Paramus, NJ 07652, US
Inventors
  • BORDEN, Laurence, A.; US
  • SMITH, Kelli, E.; US
  • WEINSHANK, Richard, L.; US
Agents
  • WHITE, John, P. ; Cooper & Dunham LLP 1185 Avenue of the Americas New York, NY 10036, US
Priority Data
08/291,29916.08.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DNA ENCODING A HUMAN BETAINE/GABA TRANSPORTER AND USES THEREOF
(FR) ADN CODANT UN TRANSPORTEUR DE BETAINE/ACIDE$g(g)-AMINOBUTIRIQUE HUMAIN ET SES UTILISATIONS
Abstract
(EN)
This invention provides an isolated nucleic acid molecules encoding mammalian betaine/GABA transporters, including a human betaine/GABA transporter. This invention further provides vectors comprising said isolated nucleic acid molecules, and mammalian cells comprising such vectors. This invention further provides isolated mammalian and human betaine/GABA transporter proteins and antibodies directed thereto. This invention provides nucleic acid molecule probes useful for detecting nucleic acid molecules encoding mammalian or human betaine/GABA transporters, antisense oligonucleotides complementary to any sequences of a nucleic acid molecules which encode a mammalian or human betaine/GABA transporter. This invention further provides pharmaceutical compounds related to mammalian and human betaine/GABA transporters, and nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian or human betaine/GABA transporter. This invention further provides methods for determining substrate binding, detecting expression, drug screening, and treatments for alleviating abnormalities associated with mammalian betaine/GABA transporters and human betaine/GABA transporters.
(FR)
L'invention concerne des molécules d'acides nucléiques isolées codant des transporteurs de bétaine/acide $g(g)-aminobutirique (GABA) de mammifère, y compris un transporteur de bétaine/GABA humain. Cette invention concerne également des vecteurs comprenant lesdites molécules d'acide nucléique isolées, ainsi que des cellules de mammifères comprenant lesdits vecteurs. De plus, l'invention concerne des protéines transporteuses de bétaine/GABA humaines et de mammifère isolées ainsi que des anticorps dirigés contre elles. En outre, l'invention concerne des sondes de molécules d'acide nucléique utiles pour détecter des molécules d'acide nucléique codant des transporteurs de bétaine/GABA humains ou de mammifère, des oligonucléotides antisens complémentaires à n'importe quelle séquence de molécules d'acide nucléique codant un transporteur de bétaine/GABA humain ou de mammifère. Par ailleurs, l'invention concerne des composés pharmaceutiques associés à des transporteurs de bétaine/GABA de mammifère et humains, ainsi que des animaux transgéniques exprimant de l'ADN codant un transporteur de bétaine/GABA de mammifère ou humain, normal ou mutant. Enfin, l'invention concerne des procédés de détermination de liaison de substrat, de détection d'expression, de criblage de médicament, ainsi que des traitements destinés à corriger des anomalies associées à des transporteurs de bétaine/GABA de mammifère et des transporteurs de bétaine/GABA humains.
Also published as
Latest bibliographic data on file with the International Bureau