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1. WO1996004789 - A METHOD OF SELECTIVELY DESTROYING NEOPLASTIC CELLS

Publication Number WO/1996/004789
Publication Date 22.02.1996
International Application No. PCT/US1995/010365
International Filing Date 15.08.1995
Chapter 2 Demand Filed 18.03.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C12N 9/02 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
02Oxidoreductases (1.), e.g. luciferase
CPC
A61K 2300/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2300Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C12N 2799/027
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2799Uses of viruses
02as vector
021for the expression of a heterologous nucleic acid
027where the vector is derived from a retrovirus
C12N 9/0079
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
0004Oxidoreductases (1.)
0071acting on paired donors with incorporation of molecular oxygen (1.14)
0077with a reduced iron-sulfur protein as one donor (1.14.15)
0079Steroid 11 beta monooxygenase (P-450 protein)(1.14.15.4)
Applicants
  • THE GENERAL HOSPITAL CORPORATION [US/US]; Fruit Street Boston, MA 02114, US
  • BOSTON UNIVERSITY [US/US]; 147 Bay State Road Boston, MA 02215, US
  • DANA FARBER CANCER INSTITUTE [US/US]; US
Inventors
  • CHIOCCA, E., Antonio; US
  • WAXMAN, David, J.; US
  • WEI, Ming, X.; US
  • BREAKEFIELD, Xandra, O.; US
  • CHEN, Ling; US
Agents
  • GOLDSTEIN, Jorge, A. ; Sterne, Kessler, Goldstein & Fox P.L.L.C. Suite 600 1100 New York Avenue, N.W. Washington, DC 20005-3934, US
Priority Data
08/291,50017.08.1994US
08/330,52328.10.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) A METHOD OF SELECTIVELY DESTROYING NEOPLASTIC CELLS
(FR) PROCEDE DE DESTRUCTION SELECTIVE DE CELLULES NEOPLASIQUES
Abstract
(EN)
A method for selectively killing nervous system and peripheral neoplastic cells is provided. Viral vectors are used to selectively express a cytochrome P450 gene in neoplastic cells, whose gene product targets the cells for selective killing, by rendering the cells sensitive to a chemotherapeutic agent.
(FR)
Procédé de destruction sélective de cellules néoplasiques dans le système nerveux central et périphérique. Les vecteurs viraux sont utilisés pour exprimer de manière sélective un gène cytochrome P450 dans des cellules néoplasiques dont le produit génétique se dirige contre les cellules devant être détruites de manière sélective en rendant ces cellules sensibles à un agent chimiothérapique.
Also published as
Latest bibliographic data on file with the International Bureau