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1. WO1996004567 - METHOD AND SYSTEM FOR MRI DETECTION OF ABNORMAL BLOOD FLOW

Publication Number WO/1996/004567
Publication Date 15.02.1996
International Application No. PCT/US1995/009255
International Filing Date 24.07.1995
Chapter 2 Demand Filed 14.02.1996
IPC
G01R 33/28 2006.01
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
28Details of apparatus provided for in groups G01R33/44-G01R33/6496
G01R 33/561 2006.01
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
44using nuclear magnetic resonance
48NMR imaging systems
54Signal processing systems, e.g. using pulse sequences
56Image enhancement or correction, e.g. subtraction or averaging techniques
561by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences
G01R 33/563 2006.01
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
44using nuclear magnetic resonance
48NMR imaging systems
54Signal processing systems, e.g. using pulse sequences
56Image enhancement or correction, e.g. subtraction or averaging techniques
563of moving material, e.g. flow-contrast angiography
CPC
A61B 5/055
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; ; Measuring using microwaves or radiowaves
055involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
G01R 33/281
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
28Details of apparatus provided for in groups G01R33/44 - G01R33/64
281Means for the use of in vitro contrast agents
G01R 33/5617
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
44using nuclear magnetic resonance [NMR]
48NMR imaging systems
54Signal processing systems, e.g. using pulse sequences ; , Generation or control of pulse sequences
56Image enhancement or correction, e.g. subtraction or averaging techniques ; , e.g. improvement of signal-to-noise ratio and resolution
561by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences
5615Echo train techniques involving acquiring plural, differently encoded, echo signals after one RF excitation, e.g. using gradient refocusing in echo planar imaging [EPI], RF refocusing in rapid acquisition with relaxation enhancement [RARE] or using both RF and gradient refocusing in gradient and spin echo imaging [GRASE]
5617using RF refocusing, e.g. RARE
G01R 33/56308
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
44using nuclear magnetic resonance [NMR]
48NMR imaging systems
54Signal processing systems, e.g. using pulse sequences ; , Generation or control of pulse sequences
56Image enhancement or correction, e.g. subtraction or averaging techniques ; , e.g. improvement of signal-to-noise ratio and resolution
563of moving material, e.g. flow contrast angiography
56308Characterization of motion or flow; Dynamic imaging
G01R 33/56366
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
44using nuclear magnetic resonance [NMR]
48NMR imaging systems
54Signal processing systems, e.g. using pulse sequences ; , Generation or control of pulse sequences
56Image enhancement or correction, e.g. subtraction or averaging techniques ; , e.g. improvement of signal-to-noise ratio and resolution
563of moving material, e.g. flow contrast angiography
56366Perfusion imaging
Applicants
  • THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; Office of Technology Transfer, National Institutes of Health, Suite 325, 6011 Executive Boulevard Rockville, MD 20852, US
Inventors
  • MOONEN, Chrit, T., W.; US
  • DUYN, Jeff; US
  • VAN GELDEREN, Peter; US
Agents
  • FEILER, William, S.; Morgan & Finnegan, L.L.P. 345 Park Avenue New York, NY 10154, US
Priority Data
08/286,78305.08.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD AND SYSTEM FOR MRI DETECTION OF ABNORMAL BLOOD FLOW
(FR) PROCEDE ET SYSTEME DE DETECTION PAR RMN (RESONANCE MAGNETIQUE NUCLEAIRE) D'ECOULEMENT DE SANG ANORMAL
Abstract
(EN)
A magnetic resonance imaging system and method for detecting blood flow abnormalities according to the time delay for the arrival of a bolus of a MR contrast agent into localized regions as observed in a temporal series magnetic resonance signals or images obtained subsequent to bolus injection. A rapid series of imaging pulse sequences acquires the time development of the signal from localized regions within the imaged field of view of a body. During the imaging period, a bolus of a MR contrat agent is injected into the cardiovascular system of the body. As the MR contrast material circulates through the imaged region, the associated field gradient which extends into the surrounding tissue results in signal losses in the acquired signal from these regions. The arrival time for the bolus into a given localized region is determined from the acquired time data, and the relative arrival time among regions in the imaged field of view indicates whether there is decreased blood flow to certain areas.
(FR)
L'invention se rapporte à un système d'imagerie par résonance magnétique et à un procédé de détection d'anomalies d'écoulement de sang en fonction du retard d'arrivée d'un bol d'un agent de contraste de résonance magnétique dans des régions localisées, retard qui a été observé grâce à des images ou signaux à résonance magnétique en série temporelle obtenus après injection du bol. Le développement temporel du signal provenant de régions localisées à l'intérieur du champ d'un corps soumis à examen par imagerie s'obtient par une série rapide de séquences impulsionnelles d'imagerie. Pendant la période d'imagerie, un bol d'un agent de contraste de résonance magnétique est injecté dans le système cardiovasculaire du corps. Lorsque ce matériau de contraste circule dans la région d'imagerie, le gradient du champ associé qui s'étend dans le tissu environnant entraîne des pertes du signal obtenu en provenance de ces régions. Le temps d'arrivée du bol dans une région localisée donnée est déterminé par les données temporelles résultantes, et les différences de temps d'arrivée d'une région à l'autre dans le champ soumis à examen par imagerie indiquent s'il y a diminution de l'écoulement de sang dans certaines zones.
Also published as
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