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1. WO1996004389 - RTK/CYTOKINE RECEPTOR CHIMERAS

Publication Number WO/1996/004389
Publication Date 15.02.1996
International Application No. PCT/US1995/009952
International Filing Date 04.08.1995
Chapter 2 Demand Filed 21.02.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/71 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
71for growth factors; for growth regulators
C07K 14/715 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
715for cytokines; for lymphokines; for interferons
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/71
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
71for growth factors; for growth regulators
C07K 14/715
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
715for cytokines; for lymphokines; for interferons
C07K 2319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
Applicants
  • REGENERON PHARMACEUTICALS, INC. [US/US]; 777 Old Saw Mill River Road Tarrytown, NY 10591, US
Inventors
  • STAHL, Neil; US
  • FARRUGGELLA, Thomas; US
  • YANCOPOULOS, George, D.; US
Agents
  • KEMPLER, Gail, M.; Regeneron Pharmaceuticals, Inc. 777 Old Saw Mill River Road Tarrytown, NY 10591 , US
  • GOLDIN, Douglas, Michael; J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5LX, GB
Priority Data
08/285,99004.08.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) RTK/CYTOKINE RECEPTOR CHIMERAS
(FR) RECEPTEURS CHIMERES DE RTK/CYTOKINE
Abstract
(EN)
Chimeric receptors consisting of extracellular domains of receptor tyrosine kinases and cytoplasmic domains of cytokines, methods for their production and their use in targeting cytokine responsive cells are described.
(FR)
L'invention porte sur des récepteurs chimères consistant en domaines extracellulaire de tyrosine kinases réceptrices et en domaines cytoplasmiques de cytokines, sur leurs méthodes de production, et sur leur utilisation pour le ciblage de cellules répondant à la cytokine.
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