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1. WO1996004381 - S. AUREUS FIBRONECTIN BINDING PROTEIN POLYPEPTIDES AND USES THEREOF

Publication Number WO/1996/004381
Publication Date 15.02.1996
International Application No. PCT/EP1995/003040
International Filing Date 28.07.1995
Chapter 2 Demand Filed 24.02.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/31 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
305from Micrococcaceae (F)
31from Staphylococcus (G)
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/31
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
305from Micrococcaceae (F)
31from Staphylococcus (G)
Applicants
  • SMITHKLINE BEECHAM PLC [GB/GB]; New Horizons Court Brentford Middlesex TW8 9EP, GB (AllExceptUS)
  • CRITCHLEY, Ian, Alfred [GB/GB]; GB (UsOnly)
  • DODD, Ian [GB/GB]; GB (UsOnly)
  • BARNETT, Paul [GB/GB]; GB (UsOnly)
  • McBAY, Diane, Louise [GB/GB]; GB (UsOnly)
Inventors
  • CRITCHLEY, Ian, Alfred; GB
  • DODD, Ian; GB
  • BARNETT, Paul; GB
  • McBAY, Diane, Louise; GB
Agents
  • VALENTINE, Jill, Barbara; SmithKline Beecham Corporate Intellectual Property SB House, Great West Road Brentford, Middlesex TW8 9BD, GB
  • GIDDINGS, Peter, John; Corporate Patents SmithKline Beecham Mundells, Welwyn Garden City Hertfordshire AL7 1EY, GB
Priority Data
9415900.105.08.1994GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) S. AUREUS FIBRONECTIN BINDING PROTEIN POLYPEPTIDES AND USES THEREOF
(FR) POLYPEPTIDES DE PROTEINE LIANT LA FIBRONECTINE DU S. AUREUS, ET LEURS UTILISATIONS
Abstract
(EN)
An isolated D3D4 polypeptide from a $i(Staphylococcus aureus) Fbp, processes for its preparation and its use in the prevention of adhesion of bacteria, in particular gram positive bacteria, to extracellular matrix proteins on in-dwelling devices or to extracellular matrix proteins in wounds and also oral pathogens, to extracellular matrix proteins on surfaces in the oral cavity, in particular tooth surfaces.
(FR)
La présente invention concerne un polypeptide D3D4 isolé dans un Fbp du $i(Staphylococcus aureus), des procédés utilisables pour sa préparation et son utilisation dans la prévention de l'adhésion de bactéries, en l'occurrence de bactéries à Gram positives, contre les protéines matricielles extracellulaires se déposant sur les dispositif placés à demeure ou contre les protéines matricielles extracellulaires se trouvant dans les blessures, et également dans la prévention des pathogènes buccaux adhérant aux protéines matricielles extracellulaires se déposant sur les surfaces de la cavité buccale.
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