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1. WO1996004378 - CHIMERIC PROTEINS AND MUTEINS OF TISSUE FACTOR PATHWAY INHIBITORS TFPI AND TFPI-2

Publication Number WO/1996/004378
Publication Date 15.02.1996
International Application No. PCT/US1995/009464
International Filing Date 25.07.1995
Chapter 2 Demand Filed 06.02.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/81 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
81Protease inhibitors
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/8114
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
81Protease inhibitors
8107Endopeptidase (E.C. 3.4.21-99) inhibitors
811Serine protease (E.C. 3.4.21) inhibitors
8114Kunitz type inhibitors
C07K 2319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
Applicants
  • CHIRON CORPORATION [US/US]; 4560 Horton Street Emeryville, CA 94608, US
Inventors
  • INNIS, Michael, A.; US
  • CREASEY, Alba, A.; US
Agents
  • SAVEREIDE, Paul, B. ; Chiron Corporation Intellectual Property - R440 P.O. Box 8097 Emeryville, CA 94662-8097, US
Priority Data
08/286,52105.08.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CHIMERIC PROTEINS AND MUTEINS OF TISSUE FACTOR PATHWAY INHIBITORS TFPI AND TFPI-2
(FR) PROTEINES CHIMERIQUES ET MUTEINES DES INHIBITEURS DES VOIES DU FACTEUR TISSULAIRE DE LA COAGULATION TFPI ET TFPI-2
Abstract
(EN)
Chimeric proteins possessing Kunitz-type domain 1 of TFPI-2 and Kunitz-type domain 2 of TFPI are disclosed, as are muteins of TFPI and TFPI-2. Nucleic acid sequences, expression vectors and transformed host cells encoding and capable of producing the disclosed chimeric proteins and muteins are also disclosed. Finally, methods for prevention and treatment of septic shock using the chimeric proteins and muteins are disclosed.
(FR)
Protéines chimériques qui possèdent le domaine 1 de type Kunitz de TFPI-2 et le domaine 2 de type Kunitz de TFPI, ainsi que mutéines de TFPI et TFPI-2. Des séquences d'acides nucléiques, des vecteurs d'expression et des cellules hôtes transformées codant les protéines chimériques et les mutéines selon la présente invention et capables de les produire sont également décrits. Enfin, l'invention concerne aussi des procédés de prévention et de traitement du choc septique à l'aide desdites protéines chimériques et mutéines.
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