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1. WO1996004376 - HEPATITIS A VIRUS RECEPTOR AND METHODS OF USE

Publication Number WO/1996/004376
Publication Date 15.02.1996
International Application No. PCT/US1995/009941
International Filing Date 04.08.1995
Chapter 2 Demand Filed 04.03.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
CPC
A01K 2217/05
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
05Animals comprising random inserted nucleic acids (transgenic)
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C12N 2799/021
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2799Uses of viruses
02as vector
021for the expression of a heterologous nucleic acid
Y02A 50/464
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
50in human health protection
30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
46Medical treatment of waterborne diseases characterized by the agent
462The waterborne disease being caused by a virus
463the virus being the Hepatitis A virus [HAV]
464the medicinal preparation containing antigens or antibodies, e.g. vaccines, antisera
Applicants
  • THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; National Institutes of Health, Office of Technology Transfer, 6011 Executive Boulevard Rockville, MD 20852, US
Inventors
  • KAPLAN, Gerardo; US
  • FEINSTONE, Stephen, M.; US
Agents
  • NEEDLE, William, H. ; Needle & Rosenberg Suite 1200 127 Peachtree Street N.E. Atlanta, GA 30303-1811, US
  • DEAN, John, Paul; Withers & Rogers 4, Dyer's Buildings Holborn London EC1N 2JT, GB
Priority Data
08/287,00105.08.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HEPATITIS A VIRUS RECEPTOR AND METHODS OF USE
(FR) RECEPTEUR DU VIRUS DE L'HEPATITE A ET PROCEDES D'UTILISATION DE CELUI-CI
Abstract
(EN)
Provided is the discovery and isolation of a cellular receptor for hepatitis A virus. Also provided is an isolated nucleic acid molecule comprising a nucleic acid encoding a polypeptide having the biological activity of a hepatitis A virus receptor. Also provided are vectors comprising the isolated nucleic acids encoding a hepatitis A virus receptor in host suitable for expression of the nucleic acids encoding the hepatitis receptor, fragments of the hepatitis A virus receptor, or homologs of the hepatitis A virus receptor. Further provided is a nonhuman transgenic animal which expresses a hepatitis A virus receptor, but does not express an endogenous, active hepatitis A virus receptor. Also provided is a method for screening drugs or vaccines utilizing the transgenic animal expressing a hepatitis A virus receptor. Also provided are methods for use of the purified hepatitis A virus receptor, such as separating hepatitis A virus from blood or other samples, detecting the presence of hepatitis A virus in a sample, determining the anti-hepatitis A virus binding of a compound, preventing hepatitis A virus infection in a subject, or treating a subject infected with hepatitis A virus. Also provided are nucleic acids which selectively hybridize with the nucleic encoding the hepatitis A virus receptor of the present invention.
(FR)
L'invention concerne la découverte et l'isolation d'un récepteur cellulaire du virus de l'hépatite A. Elle concerne également l'isolation d'une molécule d'acide nucléique contenant un acide nucléique codant pour un polypeptide ayant l'activité biologique d'un récepteur du virus de l'hépatite A, ainsi que des vecteurs contenant les acides nucléiques isolés codant pour le récepteur du virus de l'hépatite A chez un hôte capable d'exprimer les acides nucléiques codant pour le récepteur du virus de l'hépatite A, des fragments du récepteur de virus de l'hépatite A ou des homologues du récepteur du virus de l'hépatite A. L'invention concerne, par ailleurs, un animal transgénique qui exprime un récepteur du virus de l'hépatite A, mais n'exprime pas un récepteur endogène et actif du virus de l'hépatite A, ainsi qu'un procédé pour effectuer une sélection rapide de médicaments ou vaccins utilisant l'animal transgénique exprimant un récepteur du virus de l'hépatite A. L'invention concerne encore des procédés d'utilisation du récepteur purifié du virus de l'hépatite A, consistant par exemple à séparer le virus de l'hépatite A du sang ou d'autres échantillons, à détecter la présence du virus de l'hépatite A dans un échantillon, à déterminer la capacité de fixation d'un composé agissant contre le virus de l'hépatite A, à empêcher l'infection d'un sujet par le virus de l'hépatite A ou à traiter un sujet infecté par le virus de l'hépatite A. Enfin, elle concerne des acides nucléiques capables d'une hybridation sélective avec l'acide nucléique codant pour le récepteur du virus de l'hépatite A de la présente invention.
Also published as
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