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1. WO1996004312 - SMALL CELL LUNG CARCINOMA PEPTIDES AND BINDING AGENTS

Publication Number WO/1996/004312
Publication Date 15.02.1996
International Application No. PCT/GB1995/001795
International Filing Date 31.07.1995
Chapter 2 Demand Filed 01.02.1996
IPC
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 16/30 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
CPC
C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 16/3023
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
3023Lung
Applicants
  • CELLTECH THERAPEUTICS LIMITED [GB/GB]; 216 Bath Road Slough SL1 4EN, GB (AllExceptUS)
  • LAWSON, Alastair, David, Griffiths [GB/GB]; GB (UsOnly)
Inventors
  • LAWSON, Alastair, David, Griffiths; GB
Agents
  • MERCER, Christopher, Paul; Carpmaels & Ransford 43 Bloomsbury Square London WC1A 2RA, GB
Priority Data
9415492.901.08.1994GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SMALL CELL LUNG CARCINOMA PEPTIDES AND BINDING AGENTS
(FR) PEPTIDES DU CANCER PULMONAIRE A PETITES CELLULES ET AGENTS DE LIAISON
Abstract
(EN)
Binding agents, such as antibodies, are described which selectively bind to the cluster-w4 polypeptide of human small cell lung carcinoma cells at a site located at and around valine-57 of the cluster-w4 polypeptide. The binding agents, either alone or linked to a reporter or effector molecule are of use in the diagnosis or treatment of human small cell lung carcinoma. Also described are peptides (A)m-(T)n-(T)o-(K)p-V-(A)q-(G)r-(G)s-(A)t-(L)u having at least one of the core structures K-V-A, T-K-V, or V-A-G for use in the identification and/or preparation of binding agents according to the invention, as diagnostic reagents, or as immunostimulants.
(FR)
L'invention se rapporte à des agents de liaison, tels que des anticorps, qui se fixent sélectivement au polypeptide de l'agrégat w4 des cellules du cancer pulmonaire humain à petites cellules sur un site situé au niveau et autour de la valine 57 du polypeptide de l'agrégat w4. Les agents de liaison, soit seuls, soit liés à une molécule à fonction de rapporteur ou d'effecteur, sont utilisés dans le diagnostic ou le traitement du cancer pulmonaire à petites cellules chez l'homme. L'invention se rapporte également à des peptides (A)m-(T)n-(T)o-(K)p-V-(A)q-(G)r-(G)s-(A)t-(L)u, présentant au moins une des structures centrales K-V-A, T-K-V ou V-A-G, et s'utilisant dans l'identification et/ou la préparation d'agents de liaison de l'invention, comme réactifs de diagnostic ou comme immunostimulants.
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