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1. WO1996004311 - MONOCLONAL ANTIBODY TO NITROTYROSINE, METHODS FOR DIAGNOSIS AND METHODS FOR TREATMENT OF DISEASE

Publication Number WO/1996/004311
Publication Date 15.02.1996
International Application No. PCT/US1995/009843
International Filing Date 03.08.1995
Chapter 2 Demand Filed 07.03.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 47/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A61K 49/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
C07K 16/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
C07K 16/44 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
44against material not provided for elsewhere
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 47/6845
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
6835the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
6845the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
A61K 49/0004
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
0004Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
C07K 16/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
C07K 16/44
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
44against material not provided for elsewhere ; , e.g. haptens, metals, DNA, RNA, amino acids
G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
Applicants
  • UNIVERSITY OF ALABAMA AT BIRMINGHAM RESEARCH FOUNDATION [US/US]; 701 20th Street South Birmingham, AL 35294-0111, US
Inventors
  • BECKMAN, Joseph, S.; GB
  • YE, Yao, Zu; GB
Agents
  • ADLER, Benjamin, A.; 8011 Candle Lane Houston, TX 77071, US
Priority Data
08/285,41403.08.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MONOCLONAL ANTIBODY TO NITROTYROSINE, METHODS FOR DIAGNOSIS AND METHODS FOR TREATMENT OF DISEASE
(FR) ANTICORPS MONOCLONAL DIRIGE CONTRE LA NITROTYROSINE, PROCEDES DE DIAGNOSTIC ET PROCEDES THERAPEUTIQUES
Abstract
(EN)
Nitrotyrosine residues in proteins are shown by histological staining studies to be a marker for oxidative damage to tissues in animals and in humans. Nitrotyrosine at sites of inflammation or in tumors can be detected by monoclonal antibodies specific to nitrotyrosine. Such antinitrotyrosine antibodies can be used in standard immunological methods for qualitative or quantitative assays of nitrotyrosine to diagnose various pathological conditions. The antibodies can be conjugated to various diagnostic or therapeutic agents, and the conjugates used to direct the diagnostic or therapeutic agents to sites of oxidative damage in living animals or humans.
(FR)
Des examens histologiques par coloration démontrent que des restes de nitrotyrosine dans des protéines sont un marqueur de détérioration de tissus par oxydation chez l'animal et chez l'homme. On peut détecter la nitrotyrosine au niveau de sites d'inflammation ou dans des tumeurs au moyen d'anticorps monoclonaux spécifiques contre la nitrotyrosine. On peut utiliser ces anticorps dans des procédés immunologiques normalisés de détermination et de dosage de la nitrotyrosine, afin de diagnostiquer différents états pathologiques. On peut conjuguer ces anticorps à différents agents diagnostiques et thérapeutiques et utiliser ces conjugués pour diriger lesdits agents diagnostiques et thérapeutiques vers des sites de détérioration par oxydation chez l'animal et chez l'homme.
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