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1. WO1996004307 - ASP?B1¿ INSULIN ANALOGS

Publication Number WO/1996/004307
Publication Date 15.02.1996
International Application No. PCT/US1995/009768
International Filing Date 01.08.1995
Chapter 2 Demand Filed 18.12.1995
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/62 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
62Insulins
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/62
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
62Insulins
Y10S 530/866
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
530Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
866involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain
Applicants
  • ELI LILLY AND COMPANY [US/US]; Lilly Corporate Center Indianapolis, IN 46285, US (AllExceptUS)
  • BREMS, David, Nettleship [US/US]; US (UsOnly)
  • BAKAYSA, Diane, Lee [US/US]; US (UsOnly)
Inventors
  • BREMS, David, Nettleship; US
  • BAKAYSA, Diane, Lee; US
Agents
  • LAMMERT, Steven, R.; Barnes & Thornburg 1313 Merchants Bank Building 11 South Meridian Street Indianapolis, IN 46204, US
Priority Data
08/285,66102.08.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ASPB1 INSULIN ANALOGS
(FR) ANALOGUES D'INSULINE ASPB1
Abstract
(EN)
Analogs of humain insulin containing an aspartic acid at position 1 of the B chain (AspB1), and optionally, having a gln modification at position 13 (GlnB13), display modified physico-chemical and pharmacokinetic properties which enable them to be long acting. These analogs are useful in the treatment of hyperglycemia because they are soluble and display an increased tendency to self-associate.
(FR)
Cette invention se rapporte à des analogues de l'insuline humaine, qui contiennent un acide aspartique à la position 1 de la chaine B (AspB1), et qui présentent éventuellement une modification gln à la position 13 (GlnB13). Ces composés ont des propriétés physicochimiques et pharmacocynétiques modifiées, qui leur permettent d'être actifs longtemps. Ces analogues sont utiles dans le traitement de l'hyperglycémie, parce qu'ils sont solubles et qu'ils ont une tendance accrue à s'auto-associer.
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