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1. (WO1996004307) ASP?B1¿ INSULIN ANALOGS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1996/004307    International Application No.:    PCT/US1995/009768
Publication Date: 15.02.1996 International Filing Date: 01.08.1995
Chapter 2 Demand Filed:    18.12.1995    
A61K 38/00 (2006.01), C07K 14/62 (2006.01)
Applicants: ELI LILLY AND COMPANY [US/US]; Lilly Corporate Center, Indianapolis, IN 46285 (US) (For All Designated States Except US).
BREMS, David, Nettleship [US/US]; (US) (For US Only).
BAKAYSA, Diane, Lee [US/US]; (US) (For US Only)
Inventors: BREMS, David, Nettleship; (US).
BAKAYSA, Diane, Lee; (US)
Agent: LAMMERT, Steven, R.; Barnes & Thornburg, 1313 Merchants Bank Building, 11 South Meridian Street, Indianapolis, IN 46204 (US)
Priority Data:
08/285,661 02.08.1994 US
Abstract: front page image
(EN)Analogs of humain insulin containing an aspartic acid at position 1 of the B chain (Asp?B1¿), and optionally, having a gln modification at position 13 (Gln?B13¿), display modified physico-chemical and pharmacokinetic properties which enable them to be long acting. These analogs are useful in the treatment of hyperglycemia because they are soluble and display an increased tendency to self-associate.
(FR)Cette invention se rapporte à des analogues de l'insuline humaine, qui contiennent un acide aspartique à la position 1 de la chaine B (Asp?B1¿), et qui présentent éventuellement une modification gln à la position 13 (Gln?B13¿). Ces composés ont des propriétés physicochimiques et pharmacocynétiques modifiées, qui leur permettent d'être actifs longtemps. Ces analogues sont utiles dans le traitement de l'hyperglycémie, parce qu'ils sont solubles et qu'ils ont une tendance accrue à s'auto-associer.
Designated States: AM, AT, AU, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LT, LU, LV, MD, MG, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TT, UA, UG, US, UZ, VN.
African Regional Intellectual Property Organization (KE, MW, SD, SZ, UG)
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)