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1. WO1996004302 - NOVEL TUMOR MARKER FOR LUNG CANCER

Publication Number WO/1996/004302
Publication Date 15.02.1996
International Application No. PCT/EP1995/002962
International Filing Date 26.07.1995
Chapter 2 Demand Filed 26.02.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 47/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A61K 51/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier
04Organic compounds
08Peptides, e.g. proteins
10Antibodies or immunoglobulins; Fragments thereof
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 16/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 47/6857
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
6835the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
6851the antibody targeting a determinant of a tumour cell
6857the tumour determinant being from lung cancer cell
A61K 51/1054
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier ; , i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
04Organic compounds
08Peptides, e.g. proteins ; , carriers being peptides, polyamino acids, proteins
10Antibodies or immunoglobulins; Fragments thereof ; , the carrier being an antibody or an immunoglobulin, or a fragment thereof, e.g. a camelised human single domain antibody, or the Fc fragment of an antibody
1003not used, see subgroups
1045against animal or human tumor cells or tumor cell determinants
1054the tumor cell being from lung
C07K 14/4727
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4727Mucins, e.g. human intestinal mucin
C07K 16/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
Applicants
  • F. HOFFMANN-LA ROCHE AG [CH/CH]; 124 Grenzacherstrasse CH-4002 Basle, CH (AllExceptUS)
  • COCCIOLO, Maria, Gabriella [IT/IT]; IT (UsOnly)
  • GRASSI, Cinzia [IT/IT]; IT (UsOnly)
  • MAURER, Andreas [CH/CH]; CH (UsOnly)
  • PIZZORNO, Beatrice [IT/IT]; IT (UsOnly)
Inventors
  • COCCIOLO, Maria, Gabriella; IT
  • GRASSI, Cinzia; IT
  • MAURER, Andreas; CH
  • PIZZORNO, Beatrice; IT
Agents
  • COTTONG, Norbert, A. ; P.O. Box 3255 CH-4002 Basle, CH
Priority Data
94202268.205.08.1994EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL TUMOR MARKER FOR LUNG CANCER
(FR) NOUVEAU MARQUEUR TUMORAL DU CANCER DU POUMON
Abstract
(EN)
The invention provides a new tumor marker for lung cancer, which is derived from a lung cancer antigen which is a glycoprotein recognized by a monoclonal antibody selected from the group consisting of monoclonal antibodies P14B4 (DSM ACC2170) and P6F7 (DSM ACC2171), a monoclonal antibody recognizing this lung cancer antigen, a reagent and a test kit for diagnosis of lung cancer, an imaging agent, an immunotoxin and a vaccine, which contain such a monoclonal antibody, as well as methods for diagnosing lung cancer which use such a monoclonal antibody.
(FR)
L'invention concerne un nouveau marqueur tumoral du cancer du poumon, qui provient d'un antigène de cancer du poumon constitué par une glycoprotéine reconnue par un anticorps monoclonal choisi dans le groupe des anticorps monoclonaux P14B4 (DSM ACC2170) et P6F7 (DSM ACC2171). Elle concerne aussi un anticorps monoclonal reconnaissant cet antigène de cancer du poumon, un réactif et une trousse d'essai destinés au diagnostic du cancer du poumon, un agent d'imagerie, une immunotoxine et un vaccin, qui contient cet anticorps monoclonal, ainsi que des procédés permettant de diagnostiquer le cancer du poumon et qui impliquent d'utiliser cet anticorps monoclonal.
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