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1. WO1996004298 - PURIFIED FORM OF STREPTOGRAMINES, PREPARATION OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Publication Number WO/1996/004298
Publication Date 15.02.1996
International Application No. PCT/FR1995/001026
International Filing Date 31.07.1995
Chapter 2 Demand Filed 01.02.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 5/078 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
078the first amino acid being heterocyclic, e.g. Pro, His, Trp
C07K 7/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 5/06182
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
06139with the first amino acid being heterocyclic
06182and Pristinamycin II; Derivatives thereof
C07K 7/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
Applicants
  • RHONE-POULENC RORER S.A. [FR/FR]; 20, avenue Raymond-Aron F-92160 Antony, FR (AllExceptUS)
  • ANGER, Pascal [FR/FR]; FR (UsOnly)
  • BARRIERE, Jean-Claude [FR/FR]; FR (UsOnly)
  • BONNAVAUD, Bertrand [FR/FR]; FR (UsOnly)
  • LEFEVRE, Patrick [FR/FR]; FR (UsOnly)
  • PARIS, Jean-Marc [FR/FR]; FR (UsOnly)
  • THIBAUT, Denis [FR/FR]; FR (UsOnly)
Inventors
  • ANGER, Pascal; FR
  • BARRIERE, Jean-Claude; FR
  • BONNAVAUD, Bertrand; FR
  • LEFEVRE, Patrick; FR
  • PARIS, Jean-Marc; FR
  • THIBAUT, Denis; FR
Agents
  • LOBJOIS, Françoise; Rhône-Poulenc Rorer S.A. Direction Brevets 20, avenue Raymond-Aron F-92165 Antony Cédex, FR
Priority Data
94/0956402.08.1994FR
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) PURIFIED FORM OF STREPTOGRAMINES, PREPARATION OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
(FR) FORME PURIFIEE DE STREPTOGRAMINES, SA PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LA CONTIENNENT
Abstract
(EN)
Purified form of streptogramines, characterised in that it contains at least one component from group B streptogramines of general formula (I), wherein R1 is Me or Et, R2 is H or OH, and R3 is substituted benzyl of general formula (III), such that 1) if R2 is H, R is NR4R5, wherein one of R4 and R5 is H or an Me radical and the other is Me, and R' is Cl or Br, or R is (C3-5)alkenyl if R4 and R5 are Me, or 2) R is H and R' is halogen, alkylamino or dialkylamino, an ether-oxide residue, alkylthio, (C1-3)alkyl or trihalogenomethyl, or R is halogen, (C2-4)alkylamino, (C2-4)dialkylamino or methyl ethyl amino, pyrrolidino, alkenyl alkyl amino, dialkenylamino, an alkyl cycloalkylmethyl amino radical or an ether-oxide residue, alkylthio, alkylthiomethyl, (C1-6)alkyl, aryl or trihalogenomethyl, and R' is H, or R is halogen, amino, alkylamino or dialkylamino, an ether-oxide residue, an alkylthio radical, (C1-6)alkyl or trihalogenomethyl and R' is halogen, alkylamino or dialkylamino, an ether-oxide residue or alkylthio, (C1-3)alkyl, cocrystallised with one or more minor components of group A of general formula (II) wherein R'' is H, Me or Et.
(FR)
Forme purifiée de streptogramines caractérisée en ce qu'elle comprend au moins une composante du groupe B des streptogramines de formule générale (I) dans laquelle R1 est Me ou Et, R2 est H ou OH, et R3 est benzyle substitué de formule générale (III) pour lequel 1) si R2 est H, R est NR4R5 pour lequel R4 et R5 sont l'un H ou un radical Me et l'autre Me et R' est Cl ou Br, ou R est alcényle (3 à 5C) si R4 et R5 sont Me, ou bien 2) R est H et R' est halogène, alcoylamino ou dialcoylamino, un reste éther-oxyde, alcoylthio, alcoyle (1 à 3C) ou trihalogénométhyle, ou R est halogène, alcoylamino (2 à 4C), dialcoylamino (2 à 4C) ou méthyl éthyl amino, pyrrolidino, alcényl alcoyl amino, dialcénylamino, un radical alcoyl cycloalcoylméthyl amino, ou bien un reste éther-oxyde, alcoylthio, alcoylthiométhyle, alcoyle (1 à 6C), aryle ou trihalogénométhyle, et R' est H ou bien R est d'halogène, amino, alcoylamino ou dialcoylamino, un reste éther-oxyde, un radical alcoylthio, alcoyle (1 à 6C) ou trihalogénométhyle et R' est halogène, alcoylamino ou dialcoylamino, un reste éther-oxyde ou alcoylthio, alcoyle (1 à 3C), cocristallisée avec au moins une composante 'minoritaire' du groupe A de formule générale (II) dans laquelle R' est H, Me ou Et.
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