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1. WO1996004296 - PREGNANES AND CHOLANES AS NEUROCHEMICAL INITIATORS OF CHANGE IN HYPOTHALAMIC FUNCTION

Publication Number WO/1996/004296
Publication Date 15.02.1996
International Application No. PCT/US1995/009634
International Filing Date 04.08.1995
Chapter 2 Demand Filed 04.03.1996
IPC
A61K 31/56 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
A61K 31/57 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
57substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
C07J 7/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
7Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of two carbon atoms
C07J 9/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
9Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
C07J 13/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
13Normal steroids containing carbon, hydrogen, halogen, or oxygen, having a carbon-to-carbon double bond from or to position 17
C07J 41/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
41Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
CPC
A61K 31/56
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
A61K 31/568
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
565not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
568substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
A61K 31/57
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
57substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
A61K 31/573
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
57substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
573substituted in position 21, e.g. cortisone, dexamethasone, prednisone ; or aldosterone
C07J 13/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
13Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
005with double bond in position 16 (17)
C07J 13/007
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
13Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
007with double bond in position 17 (20)
Applicants
  • PHERIN CORPORATION [US/US]; Suite 240 535 Middlefield Road Menlo Park, CA 94025, US
Inventors
  • JENNINGS-WHITE, Clive, L.; US
  • BERLINER, David, L.; US
  • ADAMS, Nathan, William; US
Agents
  • SUYAT, Reginald, J.; Fish & Richardson P.C. Suite 100 2200 Sand Hill Road Menlo Park, CA 94025, US
Priority Data
08/286,07304.08.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PREGNANES AND CHOLANES AS NEUROCHEMICAL INITIATORS OF CHANGE IN HYPOTHALAMIC FUNCTION
(FR) PREGNANES ET CHOLANES EN TANT QU'INITIATEURS NEUROCHIMIQUES SERVANT A INDUIRE DES MODIFICATIONS DE LA FONCTION HYPOTHALAMIQUE
Abstract
(EN)
The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human vomeropherin, e.g. a pregnane or cholane steroid, or a pharmaceutical composition containing a vomeropherin, such that the vomeropherin binds to a specific neuroepithelial receptor. The steroid or steroids is/are preferably administered in the form of a pharmaceutical composition containing one or more pharmaceutically acceptable carriers. Other embodiments of the invention include pharmaceutical compositions containing the steroids.
(FR)
Procédé de modification de la fonction hypothalamique chez un individu consistant à lui administrer par voie nasale une vomérophérine, c.-à-d. un stéroïde du type pregnane ou cholane ou une préparation pharmaceutique la contenant de manière à ce que la vomérophérine se fixe à un récepteur neuroépithélial spécifique. Le ou lesdits stéroïdes sont de préférence administrés sous forme de préparation pharmaceutique comportant un ou plusieurs excipients compatibles. D'autres variantes de l'invention portent sur des préparations pharmaceutiques contenant lesdits stéroïdes.
Also published as
CZPV1997-329
FI970447
KR1019970700738
NO19970472
NZ291056
RO97-00231
Latest bibliographic data on file with the International Bureau