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1. WO1996004292 - 8-FLUORO-ANTHRACYCLINES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publication Number WO/1996/004292
Publication Date 15.02.1996
International Application No. PCT/EP1995/003061
International Filing Date 01.08.1995
Chapter 2 Demand Filed 26.02.1996
IPC
C07C 46/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
46Preparation of quinones
C07C 50/36 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
50Quinones
26containing groups having oxygen atoms singly bound to carbon atoms
36the quinoid structure being part of a condensed ring system having four or more rings
C07C 50/38 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
50Quinones
38containing -CHO or non-quinoid keto groups
C07H 15/252 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
20Carbocyclic rings
24Condensed ring systems having three or more rings
252Naphthacene radicals, e.g. daunomycins, adriamycins
CPC
C07C 46/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
46Preparation of quinones
C07C 50/36
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
50Quinones
26containing groups having oxygen atoms singly bound to carbon atoms
36the quinoid structure being part of a condensed ring system having four or more rings
C07C 50/38
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
50Quinones
38containing —CHO or non—quinoid keto groups
C07H 15/252
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
20Carbocyclic rings
24Condensed ring systems having three or more rings
252Naphthacene radicals, e.g. daunomycins, adriamycins
Applicants
  • A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. [IT/IT]; Via Sette Santi, 3 I-50131 Florence, IT (AllExceptUS)
  • BRISTOL-MYERS SQUIBB S.P.A. [IT/IT]; Via del Murillo Km. 2,800 I-04010 Sermoneta, IT (AllExceptUS)
  • ANIMATI, Fabio [IT/IT]; IT (UsOnly)
  • ARCAMONE, Federico [IT/IT]; IT (UsOnly)
  • GIANNINI, Guiseppe [IT/IT]; IT (UsOnly)
  • LOMBARDI, Paolo [IT/IT]; IT (UsOnly)
  • MONTEAGUDO, Edith [AR/IT]; IT (UsOnly)
Inventors
  • ANIMATI, Fabio; IT
  • ARCAMONE, Federico; IT
  • GIANNINI, Guiseppe; IT
  • LOMBARDI, Paolo; IT
  • MONTEAGUDO, Edith; IT
Agents
  • GERVASI, Gemma; Notarbartolo & Gervasi S.r.l. Viale Bianca Maria, 33 I-20122 Milan, IT
Priority Data
MI94A00169604.08.1994IT
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 8-FLUORO-ANTHRACYCLINES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
(FR) 8-FLUORO-ANTHRACYCLINES, PROCEDES DE PREPARATION ET COMPOSITIONS PHARMACEUTIQUE LES CONTENANT
Abstract
(EN)
8-fluoro-anthracyclines of formula (I) having cis-stereochemistry between the groups 8-F and 9-OH, are described, such compounds present anti-tumor activity. Their preparation and pharmaceutical compositions containing them are also described.
(FR)
La présente invention concerne des 8-fluoro-anthracyclines représentées par la formule générale (I) et présentant une configuration stéréochimique cis entre les groupes 8-F et 9-OH. Ces composés font preuve d'une activité antitumorale. L'invention concerne également la préparation de ces composés et des compositions pharmaceutiques les contenant.
Also published as
CZPV1997-280
FI970455
GE3559/1
KR1019970700743
NO19970059
NZ291426
RO97-00229
SK13797
SK199700137
Other related publications
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