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1. WO1996004277 - PYRROLINONE-BASED PEPTIDOMIMETICS

Publication Number WO/1996/004277
Publication Date 15.02.1996
International Application No. PCT/US1995/009752
International Filing Date 02.08.1995
Chapter 2 Demand Filed 04.03.1996
IPC
C07D 207/36 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
30having two double bonds between ring members or between ring members and non-ring members
34with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
36Oxygen or sulfur atoms
CPC
C07D 207/36
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
30having two double bonds between ring members or between ring members and non-ring members
34with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
36Oxygen or sulfur atoms
C07D 207/38
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
30having two double bonds between ring members or between ring members and non-ring members
34with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
36Oxygen or sulfur atoms
382-Pyrrolones
Applicants
  • THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]; Center for Technology Transfer Suite 300 3700 Market Street Philadelphia, PA 19104-3147, US
Inventors
  • HIRSCHMANN, Ralph, F.; US
  • SMITH, Amos, B., III; US
  • SPRENGELER, Paul; US
  • HOLCOMB, Ryan, C.; US
  • KEENAN, Terence; US
  • WOOD, John, L.; US
  • GUZMAN, Mark; US
  • PASTERNAK, Alexander; US
Agents
  • ELDERKIN, Dianne, B. ; Woodcock Washburn Kurtz Mackiewicz & Norris 46th floor 1 Liberty Place Philadelphia, PA 19103, US
Priority Data
08/285,02702.08.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PYRROLINONE-BASED PEPTIDOMIMETICS
(FR) AGENTS PEPTIDOMIMETIQUES A BASE DE PYRROLINONES
Abstract
(EN)
Novel pyrrolinone-based compounds mimic or inhibit the biological and/or chemical activity of peptides, including peptide $g(b)-strand conformations. Certain compounds contain functionalized pyrrolinone units in place of one or more amino acids of a target peptide.
(FR)
Cette invention se rapporte à de nouveaux composés à base de pyrrolinones, qui imitent ou inhibent l'activité biologique et/ou chimique des peptides, y compris les conformations des brins $g(b) de peptides. Certains de ces composés contiennent des unités pyrrolinones fonctionnalisées à la place d'un ou de plusieurs acides aminés d'un peptitde cible.
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