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1. WO1996004276 - NOVEL USE AND NOVEL DERIVATIVES OF IMIDAZOLE, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Publication Number WO/1996/004276
Publication Date 15.02.1996
International Application No. PCT/FR1995/001034
International Filing Date 01.08.1995
Chapter 2 Demand Filed 12.02.1996
IPC
A61K 31/4178 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41641,3-Diazoles
4178not condensed and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
C07D 405/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
CPC
A61K 31/4178
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
41641,3-Diazoles
4178not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 13/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
02of urine or of the urinary tract, e.g. urine acidifiers
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
C07D 405/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
Applicants
  • ROUSSEL UCLAF [FR/FR]; 102, route de Noisy F-93230 Romainville, FR (AllExceptUS)
  • HECKMANN, Bertrand [FR/FR]; FR (UsOnly)
  • VEVERT, Jean-Paul [FR/FR]; FR (UsOnly)
  • ZHANG, Jidong [CN/FR]; FR (UsOnly)
Inventors
  • HECKMANN, Bertrand; FR
  • VEVERT, Jean-Paul; FR
  • ZHANG, Jidong; FR
Agents
  • VIEILLEFOSSE, Jean-Claude; Roussel-Uclaf 111, route de Noisy F-93235 Romainville Cédex, FR
Priority Data
94/0956602.08.1994FR
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) NOVEL USE AND NOVEL DERIVATIVES OF IMIDAZOLE, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
(FR) NOUVELLE UTILISATION ET NOUVEAUX DERIVES DE L'IMIDAZOLE, LEUR PROCEDE DE PREPARATION, LES NOUVEAUX INTERMEDIAIRES OBTENUS, LEUR APPLICATION A TITRE DE MEDICAMENTS ET LES COMPOSITIONS PHARMACEUTIQUES LES RENFERMANT
Abstract
(EN)
Novel products of formula (I), wherein R1 is hydroxyl, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, formyl, cycloalkyl optionally interrupted by heteroatoms, R2 and R3 are halogen, mercapto, acyl, carboxy, nitro, cyano, amino, carbamoyl, R4, -OR4, and R4 are hydrogen, alkyl, alkenyl, alkynyl, acyl, amino, -(CH2)m1-S(O)m2-X-R10, wherein m1 = 0-4, m2 = 0-2, X is a single bond or -NH-, -NH-CO-, -NH-CO-NH- and R10 is alkyl, alkenyl or aryl, and Y is optionally substituted aryl, said products being obtained in all the isomeric forms, their salts, and their novel use as medicines.
(FR)
L'invention concerne la nouvelle utilisation et des nouveaux produits de formule (I) dans lesquels: R1 représente hydryoxyle, alkyle, alkényle, alkynyle, alcoxy, alkylthio, formyle, cycloalkyle, éventuellement interrompu par hétéroatomes, R2, R3 représentent notamment halogène, mercapto, acyle, carboxy, nitro, cyano, amino, carbamoyle, R4, -OR4 avec R4 représente notamment hydrogène, alkyle, alkényle, alkynyle, acyle, amino, -(CH2)m1-S(O)m2-X-R10 avec ml = 0 à 4, m2 = 0 à 2, X représente simple liaison ou -NH-, -NH-CO-, -NH-CO-NH-, et R10 représente alkyle, alkényle ou aryle, et Y représente aryle éventuellement substitué, ces produits étant sous toutes les formes isomères et les sels, à titre de médicaments.
Also published as
FI970424
KR1019970700699
Latest bibliographic data on file with the International Bureau